STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mvaDDiphosphomevalonate decarboxylase; COG: COG3407; Pfam: PF00288,PF08544; InterPro: IPR005935; diphosphomevalonate decarboxylase [Lactobacillus antri DSM 16041]; diphosphomevalonate decarboxylase; TIGR01240; gene_1027; identified by MetaGeneAnnotator; putative. (326 aa)    
Predicted Functional Partners:
BAP85606.1
GHMP kinases N terminal domain; pfam00288; gene_1026; identified by MetaGeneAnnotator; putative; phosphomevalonate kinase [Lactobacillus rhamnosus GG]; phosphomevalonate kinase, ERG8-type, Gram-positive branch; TIGR01220; strain coidentity: ATCC 53103 = GG; synonym: Lactobacillus rhamnosus ATCC 53103.
 
 0.999
fni
Isopentenyl pyrophosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
 
  
 0.996
mvk
Mevalonate kinase; Gene_1028; identified by MetaGeneAnnotator; putative.
 
  
 0.993
BAP85557.1
COG: COG0142; Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; COG0142; Trans-Isoprenyl Diphosphate Synthases, head-to-tail; cd00685; active site lid residues [active]; aspartate-rich region 1; aspartate-rich region 2; catalytic residues [active]; chain length determination region; gene_977; geranyltranstransferase [Lactobacillus vaginalis ATCC 49540]; identified by MetaGeneAnnotator; putative; substrate binding pocket [chemical binding]; substrate-Mg2+ binding site; Belongs to the FPP/GGPP synthase family.
  
 0.940
BAP84934.1
hydroxymethylglutaryl-CoA reductase; Gene_354; identified by MetaGeneAnnotator; putative; Belongs to the HMG-CoA reductase family.
 
  
 0.915
BAP85757.1
hydroxymethylglutaryl-CoA synthase; 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the..; cd00827; 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; TIGR01835; dimer interface [polypeptide binding]; gene_1177; hydroxymethylglutaryl-CoA synthase [Lactobacillus fermentum 28-3- CHN]; identified by MetaGeneAnnotator; putative.
 
 
 0.915
dinG
XRE family transcriptional regulator; 3'-5' exonuclease.
       0.695
BAP85610.1
Peptidase; Uncharacterized protein conserved in bacteria [Function unknown]; gene_1030; identified by MetaGeneAnnotator; putative; peptidase propeptide and ypeb domain protein [Lactobacillus reuteri CF48- 3A].
       0.630
lysS
lysyl-tRNA synthetase; LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; cd04322; Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three..; cd00775; dimer interface [polypeptide binding]; gene_406; ide [...]
 
      0.512
asnS
Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as..; cd00776; COG: COG0017; Pfam: PF01336,PF00152; InterPro: IPR004522; Dimer interface [polypeptide binding]; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; cl09930; anticodon binding site; asparagine--tRNA ligase [Lactobacillus plantarum subsp. plantarum AT [...]
  
    0.493
Your Current Organism:
Lactobacillus hokkaidonensis
NCBI taxonomy Id: 1291742
Other names: L. hokkaidonensis JCM 18461, Lactobacillus hokkaidonensis JCM 18461, Lactobacillus hokkaidonensis LOOC260, Lactobacillus sp. LOOC260
Server load: low (18%) [HD]
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