node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAP84947.1 | BAP86464.1 | LOOC260_103730 | LOOC260_119580 | CoA binding site [chemical binding]; Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of..; cd03354; gene_367; identified by MetaGeneAnnotator; putative; serine O-acetyltransferase [Oenococcus oeni PSU-1]; serine O-acetyltransferase; TIGR01172; substrate binding site [chemical binding]; trimer interface [polypeptide binding]. | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.845 |
BAP84947.1 | glyA | LOOC260_103730 | LOOC260_116060 | CoA binding site [chemical binding]; Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of..; cd03354; gene_367; identified by MetaGeneAnnotator; putative; serine O-acetyltransferase [Oenococcus oeni PSU-1]; serine O-acetyltransferase; TIGR01172; substrate binding site [chemical binding]; trimer interface [polypeptide binding]. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.832 |
BAP84947.1 | metC | LOOC260_103730 | LOOC260_103720 | CoA binding site [chemical binding]; Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of..; cd03354; gene_367; identified by MetaGeneAnnotator; putative; serine O-acetyltransferase [Oenococcus oeni PSU-1]; serine O-acetyltransferase; TIGR01172; substrate binding site [chemical binding]; trimer interface [polypeptide binding]. | CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of..; cd00614; COG: COG0626; Cys/Met metabolism PLP-dependent enzyme; pfam01053; catalytic residue [active]; cystathionine beta-lyase / cystathionine gamma-lyase [Lactobacillus salivarius ATCC 11741]; gene_366; homodimer interface [polypeptide binding]; identified by MetaGeneAnnotator; putative; pyridoxal 5'-phosphate binding site [chemical binding] [...] | 0.809 |
BAP84947.1 | trpA | LOOC260_103730 | LOOC260_121300 | CoA binding site [chemical binding]; Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of..; cd03354; gene_367; identified by MetaGeneAnnotator; putative; serine O-acetyltransferase [Oenococcus oeni PSU-1]; serine O-acetyltransferase; TIGR01172; substrate binding site [chemical binding]; trimer interface [polypeptide binding]. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.816 |
BAP84947.1 | trpB | LOOC260_103730 | LOOC260_121310 | CoA binding site [chemical binding]; Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of..; cd03354; gene_367; identified by MetaGeneAnnotator; putative; serine O-acetyltransferase [Oenococcus oeni PSU-1]; serine O-acetyltransferase; TIGR01172; substrate binding site [chemical binding]; trimer interface [polypeptide binding]. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.813 |
BAP85395.1 | BAP86464.1 | LOOC260_108550 | LOOC260_119580 | Acetolactate synthase; PYR/PP interface [polypeptide binding]; Pyrimidine (PYR) binding domain of POX and related proteins; cd07035; TPP binding site [chemical binding]; TPP-binding site [chemical binding]; Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2..; cd02010; Thiamine pyrophosphate enzyme, central domain; pfam00205; acetolactate synthase [Lactobacillus rhamnosus GG]; acetolactate synt [...] | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.941 |
BAP85395.1 | aldA | LOOC260_108550 | LOOC260_106210 | Acetolactate synthase; PYR/PP interface [polypeptide binding]; Pyrimidine (PYR) binding domain of POX and related proteins; cd07035; TPP binding site [chemical binding]; TPP-binding site [chemical binding]; Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2..; cd02010; Thiamine pyrophosphate enzyme, central domain; pfam00205; acetolactate synthase [Lactobacillus rhamnosus GG]; acetolactate synt [...] | Aldehyde dehydrogenase family; pfam00171; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Escherichia coli lactaldehyde dehydrogenase AldA-like; cd07088; NAD binding site [chemical binding]; catalytic residues [active]; gene_598; identified by MetaGeneAnnotator; putative; lactaldehyde dehydrogenase [Lactobacillus hilgardii ATCC 8290]; substrate binding site [chemical binding]. | 0.829 |
BAP86464.1 | BAP84947.1 | LOOC260_119580 | LOOC260_103730 | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | CoA binding site [chemical binding]; Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of..; cd03354; gene_367; identified by MetaGeneAnnotator; putative; serine O-acetyltransferase [Oenococcus oeni PSU-1]; serine O-acetyltransferase; TIGR01172; substrate binding site [chemical binding]; trimer interface [polypeptide binding]. | 0.845 |
BAP86464.1 | BAP85395.1 | LOOC260_119580 | LOOC260_108550 | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase; PYR/PP interface [polypeptide binding]; Pyrimidine (PYR) binding domain of POX and related proteins; cd07035; TPP binding site [chemical binding]; TPP-binding site [chemical binding]; Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2..; cd02010; Thiamine pyrophosphate enzyme, central domain; pfam00205; acetolactate synthase [Lactobacillus rhamnosus GG]; acetolactate synt [...] | 0.941 |
BAP86464.1 | BAP86739.1 | LOOC260_119580 | LOOC260_122340 | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of..; cd00614; Cys/Met metabolism PLP-dependent enzyme; pfam01053; KEGG: lki:LKI_03365 2.3e-122 cystathionine beta-lyase; K01760 cystathionine beta-lyase; Psort location: Cytoplasmic, score: 9.97; catalytic residue [active]; cystathionine beta-lyase [Lactobacillus parafarraginis F0439]; gene_2159; homodimer interface [polypeptide binding]; identifie [...] | 0.838 |
BAP86464.1 | aldA | LOOC260_119580 | LOOC260_106210 | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Aldehyde dehydrogenase family; pfam00171; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Escherichia coli lactaldehyde dehydrogenase AldA-like; cd07088; NAD binding site [chemical binding]; catalytic residues [active]; gene_598; identified by MetaGeneAnnotator; putative; lactaldehyde dehydrogenase [Lactobacillus hilgardii ATCC 8290]; substrate binding site [chemical binding]. | 0.830 |
BAP86464.1 | glyA | LOOC260_119580 | LOOC260_116060 | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.921 |
BAP86464.1 | metAA | LOOC260_119580 | LOOC260_114020 | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.826 |
BAP86464.1 | metC | LOOC260_119580 | LOOC260_103720 | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of..; cd00614; COG: COG0626; Cys/Met metabolism PLP-dependent enzyme; pfam01053; catalytic residue [active]; cystathionine beta-lyase / cystathionine gamma-lyase [Lactobacillus salivarius ATCC 11741]; gene_366; homodimer interface [polypeptide binding]; identified by MetaGeneAnnotator; putative; pyridoxal 5'-phosphate binding site [chemical binding] [...] | 0.838 |
BAP86464.1 | thrC | LOOC260_119580 | LOOC260_119500 | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Threonine synthase; Pyridoxal-phosphate dependent enzyme; pfam00291; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan..; cl00342; catalyzes the formation of L-threonine from O-phospho-L-homoserine; gene_1876; identified by MetaGeneAnnotator; putative; threonine synthase [Lactobacillus acidophilus NCFM]. | 0.954 |
BAP86464.1 | trpA | LOOC260_119580 | LOOC260_121300 | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.924 |
BAP86464.1 | trpB | LOOC260_119580 | LOOC260_121310 | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.942 |
BAP86739.1 | BAP86464.1 | LOOC260_122340 | LOOC260_119580 | CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of..; cd00614; Cys/Met metabolism PLP-dependent enzyme; pfam01053; KEGG: lki:LKI_03365 2.3e-122 cystathionine beta-lyase; K01760 cystathionine beta-lyase; Psort location: Cytoplasmic, score: 9.97; catalytic residue [active]; cystathionine beta-lyase [Lactobacillus parafarraginis F0439]; gene_2159; homodimer interface [polypeptide binding]; identifie [...] | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.838 |
BAP86739.1 | metAA | LOOC260_122340 | LOOC260_114020 | CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of..; cd00614; Cys/Met metabolism PLP-dependent enzyme; pfam01053; KEGG: lki:LKI_03365 2.3e-122 cystathionine beta-lyase; K01760 cystathionine beta-lyase; Psort location: Cytoplasmic, score: 9.97; catalytic residue [active]; cystathionine beta-lyase [Lactobacillus parafarraginis F0439]; gene_2159; homodimer interface [polypeptide binding]; identifie [...] | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.494 |
BAP86739.1 | metC | LOOC260_122340 | LOOC260_103720 | CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of..; cd00614; Cys/Met metabolism PLP-dependent enzyme; pfam01053; KEGG: lki:LKI_03365 2.3e-122 cystathionine beta-lyase; K01760 cystathionine beta-lyase; Psort location: Cytoplasmic, score: 9.97; catalytic residue [active]; cystathionine beta-lyase [Lactobacillus parafarraginis F0439]; gene_2159; homodimer interface [polypeptide binding]; identifie [...] | CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of..; cd00614; COG: COG0626; Cys/Met metabolism PLP-dependent enzyme; pfam01053; catalytic residue [active]; cystathionine beta-lyase / cystathionine gamma-lyase [Lactobacillus salivarius ATCC 11741]; gene_366; homodimer interface [polypeptide binding]; identified by MetaGeneAnnotator; putative; pyridoxal 5'-phosphate binding site [chemical binding] [...] | 0.903 |