STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
BAP86464.1Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (345 aa)    
Predicted Functional Partners:
thrC
Threonine synthase; Pyridoxal-phosphate dependent enzyme; pfam00291; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan..; cl00342; catalyzes the formation of L-threonine from O-phospho-L-homoserine; gene_1876; identified by MetaGeneAnnotator; putative; threonine synthase [Lactobacillus acidophilus NCFM].
  
 
 0.954
trpB
Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 0.942
BAP85395.1
Acetolactate synthase; PYR/PP interface [polypeptide binding]; Pyrimidine (PYR) binding domain of POX and related proteins; cd07035; TPP binding site [chemical binding]; TPP-binding site [chemical binding]; Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2..; cd02010; Thiamine pyrophosphate enzyme, central domain; pfam00205; acetolactate synthase [Lactobacillus rhamnosus GG]; acetolactate synt [...]
 
 0.941
trpA
Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
  
 
 0.924
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.921
BAP84947.1
CoA binding site [chemical binding]; Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of..; cd03354; gene_367; identified by MetaGeneAnnotator; putative; serine O-acetyltransferase [Oenococcus oeni PSU-1]; serine O-acetyltransferase; TIGR01172; substrate binding site [chemical binding]; trimer interface [polypeptide binding].
 
  
 0.845
metC
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of..; cd00614; COG: COG0626; Cys/Met metabolism PLP-dependent enzyme; pfam01053; catalytic residue [active]; cystathionine beta-lyase / cystathionine gamma-lyase [Lactobacillus salivarius ATCC 11741]; gene_366; homodimer interface [polypeptide binding]; identified by MetaGeneAnnotator; putative; pyridoxal 5'-phosphate binding site [chemical binding] [...]
  
 
 0.838
BAP86739.1
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of..; cd00614; Cys/Met metabolism PLP-dependent enzyme; pfam01053; KEGG: lki:LKI_03365 2.3e-122 cystathionine beta-lyase; K01760 cystathionine beta-lyase; Psort location: Cytoplasmic, score: 9.97; catalytic residue [active]; cystathionine beta-lyase [Lactobacillus parafarraginis F0439]; gene_2159; homodimer interface [polypeptide binding]; identifie [...]
  
 
 0.838
aldA
Aldehyde dehydrogenase family; pfam00171; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Escherichia coli lactaldehyde dehydrogenase AldA-like; cd07088; NAD binding site [chemical binding]; catalytic residues [active]; gene_598; identified by MetaGeneAnnotator; putative; lactaldehyde dehydrogenase [Lactobacillus hilgardii ATCC 8290]; substrate binding site [chemical binding].
  
 
 0.830
metAA
Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.
   
 
 0.826
Your Current Organism:
Lactobacillus hokkaidonensis
NCBI taxonomy Id: 1291742
Other names: L. hokkaidonensis JCM 18461, Lactobacillus hokkaidonensis JCM 18461, Lactobacillus hokkaidonensis LOOC260, Lactobacillus sp. LOOC260
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