STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
pdhBPyruvate dehydrogenase E1 component subunit beta; PFAM: Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; KEGG: lbr:LVIS_1409 acetoin dehydrogenase complex, E1 component, beta subunit; SMART: Transketolase-like, pyrimidine-binding domain; Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; cd07036; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; COG0022; TPP binding site [che [...] (325 aa)    
Predicted Functional Partners:
pdhA
Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
 0.999
pdhC
Pyruvate dehydrogenase E2 component, dihydrolipoamide acetyltransferase; 2-oxoacid dehydrogenases acyltransferase (catalytic domain); pfam00198; E3 interaction surface; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid..; cd06849; acetoin/pyruvate dehydrogenase complex, E2 component, dihydrolipoamide succinyltransferase [Lactobacillus brevis ATCC 367]; branched-chain alpha-keto acid dehydrogena [...]
 0.999
pdhD
Dihydrolipoamide dehydrogenase; COG: COG1249; Pfam: PF07992,PF00070,PF02852; InterPro: IPR006258; NAD(P)-binding Rossmann-like domain; pfam13450; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; pfam02852; Pyridine nucleotide-disulphide oxidoreductase; pfam00070; dihydrolipoamide dehydrogenase [Lactobacillus hilgardii ATCC 8290]; dihydrolipoamide dehydrogenase; Reviewed; gene_332; identified by MetaGeneAnnotator; putative.
 0.987
GAK47428.1
Pyruvate kinase; Phosphohistidine swiveling domain [Signal transduction mechanisms]; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low..; cd00288; domain interfaces; gene_526; identified by MetaGeneAnnotator; putative; pyruvate kinase [Lactobacillus rhamnosus GG]; pyruvate kinase; Provisional; strain coidentity: ATCC 53103 = GG; synonym: Lactobacillus rhamnosus ATCC 53103.
  
 
 0.985
mae
Malic enzyme, NAD-dependent; Malic enzyme [Energy production and conversion]; COG0281; Malic enzyme, N-terminal domain; pfam00390; Malic enzyme, NAD binding domain; smart00919; NAD(P) binding pocket [chemical binding]; gene_663; identified by MetaGeneAnnotator; putative; malic enzyme, NAD-dependent [Lactobacillus plantarum subsp. plantarum ST- III].
  
 
 0.959
pgi
KEGG: lbr:LVIS_1312 9.0e-199 glucose-6-phosphate isomerase; K01810 glucose-6-phosphate isomerase; Psort location: Cytoplasmic, score: 9.26; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of..; cd05015; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as [...]
  
 
 0.957
hicD1
L-2-hydroxyisocaproate dehydrogenase; Gene_410; identified by MetaGeneAnnotator; putative; Belongs to the LDH/MDH superfamily.
  
 0.954
GAK47904.1
Aldehyde dehydrogenase family; pfam00171; Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; cd07100; NAD(P) binding site [chemical binding]; Succinate-semialdehyde dehydrogenase [Oenococcus kitaharae DSM 17330]; catalytic residues [active]; gene_1002; identified by MetaGeneAnnotator; putative.
  
 0.954
zwf
Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.
   
 
 0.954
pps
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
    
 0.954
Your Current Organism:
Lactobacillus oryzae
NCBI taxonomy Id: 1291743
Other names: L. oryzae JCM 18671, Lactobacillus oryzae JCM 18671, Lactobacillus oryzae SG293, Lactobacillus sp. JCM 18671, Lactobacillus sp. SG293
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