STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GAK48268.1Pyridine nucleotide-disulfide oxidoreductase family protein, partial [Lactobacillus salivarius CECT 5713]; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; pfam02852; fragment; gene_1366; identified by MetaGeneAnnotator; putative. (310 aa)    
Predicted Functional Partners:
GAK48269.1
Pyridine nucleotide-disulfide oxidoreductase family protein [Lactobacillus salivarius CECT 5713]; Rossmann-fold NAD(P)(+)-binding proteins; cl09931; fragment; gene_1367; identified by MetaGeneAnnotator; putative; pyridine nucleotide-disulfide oxidoreductase; Provisional.
     0.987
pdhC
Pyruvate dehydrogenase E2 component, dihydrolipoamide acetyltransferase; 2-oxoacid dehydrogenases acyltransferase (catalytic domain); pfam00198; E3 interaction surface; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid..; cd06849; acetoin/pyruvate dehydrogenase complex, E2 component, dihydrolipoamide succinyltransferase [Lactobacillus brevis ATCC 367]; branched-chain alpha-keto acid dehydrogena [...]
 0.964
pdhB
Pyruvate dehydrogenase E1 component subunit beta; PFAM: Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; KEGG: lbr:LVIS_1409 acetoin dehydrogenase complex, E1 component, beta subunit; SMART: Transketolase-like, pyrimidine-binding domain; Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; cd07036; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; COG0022; TPP binding site [che [...]
 
 0.946
GAK47007.1
Thioredoxin; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox..; cd02947; catalytic residues [active]; gene_105; identified by MetaGeneAnnotator; putative; strain coidentity: ATCC 53103 = GG; synonym: Lactobacillus rhamnosus ATCC 53103; thioredoxin [Lactobacillus rhamnosus GG].
  
 0.841
pdhA
Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
 
 
 0.779
GAK47900.1
Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per..; cd00340; catalytic residues [active]; dimer interface [polypeptide binding]; gene_998; glutathione peroxidase [Lactobacillus rhamnosus GG]; identified by MetaGeneAnnotator; putative; strain coidentity: ATCC 53103 = GG; synonym: Lactobacillus rhamnosus ATCC 53103.
  
 0.607
GAK47944.1
Glycine cleavage system H-protein; Gene_1042; identified by MetaGeneAnnotator; putative.
 
  
 0.593
GAK48267.1
3-beta-hydroxysteroid dehydrogenase; 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; PRK05565; 3-oxoacyl-ACP reductase [Lactobacillus brevis ATCC 367]; NAD(P) binding site [chemical binding]; Rossmann-fold NAD(P)(+)-binding proteins; cl09931; gene_1365; identified by MetaGeneAnnotator; putative.
  
   0.575
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.569
glnA
Glutamine synthetase, beta-Grasp domain; pfam03951; Glutamine synthetase, catalytic domain; pfam00120; gene_49; glutamine synthetase [Lactobacillus brevis ATCC 367]; glutamine synthetase, type I; TIGR00653; identified by MetaGeneAnnotator; putative.
  
 
 0.564
Your Current Organism:
Lactobacillus oryzae
NCBI taxonomy Id: 1291743
Other names: L. oryzae JCM 18671, Lactobacillus oryzae JCM 18671, Lactobacillus oryzae SG293, Lactobacillus sp. JCM 18671, Lactobacillus sp. SG293
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.