STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GAK48466.1Superfamily II DNA/RNA helicase; ATP binding site [chemical binding]; ATP-binding site [chemical binding]; DEAD-like helicases superfamily; smart00487; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may..; cd00079; P-loop containing Nucleoside Triphosphate Hydrolases; cl09099; gene_1564; identified by MetaGeneAnnotator; putative; nucleotide binding region [chemical binding]; putative Mg+ [...] (435 aa)    
Predicted Functional Partners:
rplC
50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
   
 
 0.868
GAK48465.1
Oxidoreductase; KEGG: lpl:lp_1161 3.4e-105 oxidoreductase (putative) K00540; Psort location: Cytoplasmic, score: 8.96; Oxidoreductase family, NAD-binding Rossmann fold; pfam01408; Predicted dehydrogenases and related proteins [General function prediction only]; COG0673; gene_1563; identified by MetaGeneAnnotator; putative; oxidoreductase, NAD-binding domain protein [Lactobacillus parafarraginis F0439].
     
 0.862
recQ
ATP-dependent DNA helicase; Gene_517; identified by MetaGeneAnnotator; putative.
 
 0.859
GAK48000.1
Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.
 
 0.845
dnaJ
Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...]
  
 
 0.840
rplD
50S ribosomal protein L4; Forms part of the polypeptide exit tunnel.
  
 0.834
nnrE
Carbohydrate kinase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family.
  
 0.829
rplM
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
 
 0.828
rplX
50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
   
 
 0.820
GAK48186.1
50S ribosomal protein L7/L12; Gene_1284; identified by MetaGeneAnnotator; putative.
   
 
 0.820
Your Current Organism:
Lactobacillus oryzae
NCBI taxonomy Id: 1291743
Other names: L. oryzae JCM 18671, Lactobacillus oryzae JCM 18671, Lactobacillus oryzae SG293, Lactobacillus sp. JCM 18671, Lactobacillus sp. SG293
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