| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cobA | cysC_2 | SH09_00565 | SH09_00540 | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | Adenylylsulfate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.792 |
| cobA | cysH | SH09_00565 | SH09_00580 | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.888 |
| cobA | cysI_2 | SH09_00565 | SH09_00570 | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | Sulfite reductase; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.940 |
| cobA | cysJ_1 | SH09_00565 | SH09_00615 | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | Sulfite reductase [NADPH] flavoprotein alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. | 0.502 |
| cobA | cysJ_2 | SH09_00565 | SH09_00575 | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | Sulfite reductase [NADPH] flavoprotein alpha-component; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.828 |
| cobA | sat | SH09_00565 | SH09_00545 | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | ATP sulfurylase; ATPS; converts ATP and sulfate to 5'phosphosulfate and pyrophosphate; in some organisms this enzyme is involved in the incorporation of inorganic sulfate while in others it is involved in the production of ATP in the reverse direction; the enzyme from Thermus thermophilus is dimeric and binds a zinc ion that is coordinated by cysteine and histidine residues that are not found in all related proteins but is found in some thermophilic organisms; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.824 |
| cobA | sirC | SH09_00565 | SH09_00555 | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | Precorrin-2 dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.998 |
| cysC_2 | cobA | SH09_00540 | SH09_00565 | Adenylylsulfate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.792 |
| cysC_2 | cysH | SH09_00540 | SH09_00580 | Adenylylsulfate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
| cysC_2 | cysI_2 | SH09_00540 | SH09_00570 | Adenylylsulfate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Sulfite reductase; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.963 |
| cysC_2 | cysJ_1 | SH09_00540 | SH09_00615 | Adenylylsulfate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Sulfite reductase [NADPH] flavoprotein alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. | 0.693 |
| cysC_2 | cysJ_2 | SH09_00540 | SH09_00575 | Adenylylsulfate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Sulfite reductase [NADPH] flavoprotein alpha-component; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.827 |
| cysC_2 | sat | SH09_00540 | SH09_00545 | Adenylylsulfate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | ATP sulfurylase; ATPS; converts ATP and sulfate to 5'phosphosulfate and pyrophosphate; in some organisms this enzyme is involved in the incorporation of inorganic sulfate while in others it is involved in the production of ATP in the reverse direction; the enzyme from Thermus thermophilus is dimeric and binds a zinc ion that is coordinated by cysteine and histidine residues that are not found in all related proteins but is found in some thermophilic organisms; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
| cysC_2 | sirC | SH09_00540 | SH09_00555 | Adenylylsulfate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Precorrin-2 dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.837 |
| cysH | cobA | SH09_00580 | SH09_00565 | Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.888 |
| cysH | cysC_2 | SH09_00580 | SH09_00540 | Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Adenylylsulfate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
| cysH | cysI_2 | SH09_00580 | SH09_00570 | Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Sulfite reductase; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.999 |
| cysH | cysJ_1 | SH09_00580 | SH09_00615 | Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Sulfite reductase [NADPH] flavoprotein alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. | 0.973 |
| cysH | cysJ_2 | SH09_00580 | SH09_00575 | Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Sulfite reductase [NADPH] flavoprotein alpha-component; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.985 |
| cysH | cysK | SH09_00580 | SH09_12575 | Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.456 |
