Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
phoRHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (567 aa)    
Predicted Functional Partners:
phoP_2
PhoP family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 0.998
vicR
PhoP family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.854
arlR_1
Response regulator ArlR; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.831
srrA
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.829
hssR_2
Heme transporter CcmC; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.789
graS
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 
 0.726
graR_2
Response regulator GraR; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.695
polA_2
DNA polymerase I; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.618
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
       0.608
mutM
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
       0.528
Your Current Organism:
Staphylococcus gallinarum
NCBI taxonomy Id: 1293
Other names: ATCC 35539, CCM 3572, CCUG 15600, CIP 103504, DSM 20610, LMG 19121, LMG:19121, NCTC 12195, NRRL B-14763, S. gallinarum, strain VIII1
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