STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AAES_124995Estradiol 17-beta-dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (390 aa)    
Predicted Functional Partners:
AAES_154554
Dehydrogenase/reductase SDR family member 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.913
AAES_124992
Short-chain dehydrogenase/reductase family 42E member 1; Belongs to the 3-beta-HSD family.
   
 
 0.888
AAES_165943
Estradiol 17-beta-dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
  
0.870
AAES_06565
Aromatase; Belongs to the cytochrome P450 family.
    
 0.862
AAES_129551
Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family.
   
 
 0.861
AAES_98766
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase-like protein.
   
 
 0.856
AAES_142192
3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)).
   
 
 0.851
AAES_149417
3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)).
   
 
 0.850
AAES_156355
3-keto-steroid reductase isoform X1.
     
 0.848
AAES_149794
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
     
 0.847
Your Current Organism:
Amazona aestiva
NCBI taxonomy Id: 12930
Other names: A. aestiva, blue-fronted amazon
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