STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AAES_04539Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (651 aa)    
Predicted Functional Partners:
AAES_62057
Cystathionine gamma-lyase.
  
 0.990
AAES_119621
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.973
AAES_41005
Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism.
  
 
 0.969
AAES_156511
S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
  
 
 0.967
AAES_49542
S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
  
 
 0.967
AAES_122318
Bifunctional purine biosynthesis protein PURH.
    
 0.928
AAES_01531
Formimidoyltransferase-cyclodeaminase-like protein.
    
 0.927
AAES_104875
Methionyl-tRNA formyltransferase.
    
 0.926
AAES_12690
Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.
  
 
 0.926
AAES_08155
Serine hydroxymethyltransferase, mitochondrial.
  
 
 0.926
Your Current Organism:
Amazona aestiva
NCBI taxonomy Id: 12930
Other names: A. aestiva, blue-fronted amazon
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.