H663_00505 protein (Limnohabitans planktonicus)

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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H663_00505

enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)

Predicted Functional Partners:

H663_11545

0.974

H663_01270

0.963

H663_00510

0.945

H663_01515

0.779

H663_15125

0.750

H663_05570

0.747

H663_11430

0.728

H663_11980

0.724

H663_09420

0.720

H663_11855

0.720

Your Current Organism:

Limnohabitans planktonicus

NCBI taxonomy Id: 1293045
Other names: L. planktonicus II-D5, Limnohabitans planktonicus II-D5, beta proteobacterium II-D5

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page 1 of 4

Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031398

Positive regulation of protein ubiquitination

4 of 9

2.81

3.58

2.34e-07

GO:1905786

Positive regulation of anaphase-promoting complex-dependent catabolic process

3 of 3

3.16

3.13

2.07e-06

GO:0010948

Negative regulation of cell cycle process

5 of 67

2.03

2.96

4.76e-07

GO:1901987

Regulation of cell cycle phase transition

5 of 88

1.91

2.65

1.32e-06

GO:0031145

Anaphase-promoting complex-dependent catabolic process

3 of 17

2.4

2.28

4.79e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990757

Ubiquitin ligase activator activity

3 of 3

3.16

2.81

8.23e-06

GO:0010997

Anaphase-promoting complex binding

3 of 3

3.16

2.81

8.23e-06

GO:0044877

Protein-containing complex binding

4 of 172

1.52

1.23

0.0015

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005680

Anaphase-promoting complex

3 of 17

2.4

1.93

0.00024

GO:0072686

Mitotic spindle

3 of 29

2.17

1.79

0.00035

GO:0099080

Supramolecular complex

4 of 179

1.51

1.29

0.00092

GO:0005634

Nucleus

9 of 2607

0.7

0.57

0.00078

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2098

Anaphase-promoting complex, and Inactivation of APC/C via direct inhibition of the APC/C complex

5 of 20

2.56

4.24

6.80e-09

CL:2101

Anaphase-promoting complex, and Mitotic checkpoint complex

4 of 15

2.58

3.51

2.24e-07

CL:12008

Mostly uncharacterized, incl. Cholestenol delta-isomerase activity, and Zinc finger

3 of 27

2.2

1.86

0.00026

CL:5421

Ndc80 complex, and IQ motif, EF-hand binding site

2 of 5

2.76

1.47

0.0021

CL:12052

Cholestenol delta-isomerase activity, and Phosphatidylinositol signaling system

2 of 5

2.76

1.47

0.0021

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04111

Cell cycle - yeast

5 of 140

1.71

2.24

4.09e-06

map04113

Meiosis - yeast

5 of 204

1.55

1.88

1.27e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-176408

Regulation of APC/C activators between G1/S and early anaphase

5 of 16

2.65

4.7

1.09e-09

MAP-453276

Regulation of mitotic cell cycle

5 of 21

2.53

4.51

1.75e-09

MAP-174143

APC/C-mediated degradation of cell cycle proteins

5 of 21

2.53

4.51

1.75e-09

MAP-69278

Cell Cycle, Mitotic

6 of 265

1.51

2.0

2.46e-06

MAP-1640170

Cell Cycle

6 of 343

1.4

1.7

8.91e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005819

Spindle

4 of 43

2.13

2.33

2.24e-05

GOCC:0072686

Mitotic spindle

3 of 15

2.46

2.14

0.00010

GOCC:0033597

Mitotic checkpoint complex

2 of 3

2.98

1.58

0.0014

GOCC:0005876

Spindle microtubule

2 of 7

2.61

1.4

0.0027

GOCC:0043226

Organelle

11 of 5129

0.49

0.39

0.0014

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033010

The WD repeat Cdc20/Fizzy family

3 of 3

3.16

2.66

1.52e-05

IPR024977

Anaphase-promoting complex subunit 4, WD40 domain

2 of 6

2.68

0.95

0.0187

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00320

WD40 repeats

3 of 134

1.51

0.72

0.0330

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node1	node2	node1 annotation	node2 annotation	score
H663_00505	H663_00510	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.945
H663_00505	H663_01270	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.963
H663_00505	H663_01515	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.779
H663_00505	H663_05570	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family.	0.747
H663_00505	H663_09420	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.720
H663_00505	H663_11430	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Lipid-transfer protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family.	0.728
H663_00505	H663_11545	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.974
H663_00505	H663_11855	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.720
H663_00505	H663_11980	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.724
H663_00505	H663_15125	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-hydroxyacyl-CoA dehydrogenase; Converts 3-hydroxyadipyl-CoA to beta-ketoadipyl-CoA in phenylacetate degradation; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.750
H663_00510	H663_00505	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.945
H663_00510	H663_01270	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.412
H663_00510	H663_05570	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family.	0.471
H663_00510	H663_11430	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Lipid-transfer protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family.	0.471
H663_00510	H663_11980	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.416
H663_00510	H663_15125	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-hydroxyacyl-CoA dehydrogenase; Converts 3-hydroxyadipyl-CoA to beta-ketoadipyl-CoA in phenylacetate degradation; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.412
H663_01270	H663_00505	3-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.963
H663_01270	H663_00510	3-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.412
H663_01270	H663_01515	3-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.473
H663_01270	H663_05570	3-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family.	0.819