node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKS72624.1 | AKS73160.1 | RN70_01150 | RN70_04110 | Lactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.833 |
AKS72624.1 | AKS73246.1 | RN70_01150 | RN70_04560 | Lactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. | Pyruvate oxidase; Catalyzes the formation of acetyl phosphate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. | 0.912 |
AKS72624.1 | ilvA | RN70_01150 | RN70_04080 | Lactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.818 |
AKS72624.1 | ilvB | RN70_01150 | RN70_04115 | Lactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. | Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.825 |
AKS72624.1 | leuA | RN70_01150 | RN70_04100 | Lactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.829 |
AKS72624.1 | leuC | RN70_01150 | RN70_04090 | Lactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. | Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.819 |
AKS72624.1 | leuD | RN70_01150 | RN70_04085 | Lactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. | Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.810 |
AKS73160.1 | AKS72624.1 | RN70_04110 | RN70_01150 | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Lactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. | 0.833 |
AKS73160.1 | AKS73246.1 | RN70_04110 | RN70_04560 | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pyruvate oxidase; Catalyzes the formation of acetyl phosphate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. | 0.977 |
AKS73160.1 | ilvA | RN70_04110 | RN70_04080 | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.990 |
AKS73160.1 | ilvB | RN70_04110 | RN70_04115 | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
AKS73160.1 | ilvC | RN70_04110 | RN70_04105 | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.998 |
AKS73160.1 | ilvD | RN70_04110 | RN70_04120 | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. | 0.976 |
AKS73160.1 | leuA | RN70_04110 | RN70_04100 | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.993 |
AKS73160.1 | leuB | RN70_04110 | RN70_04095 | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.996 |
AKS73160.1 | leuC | RN70_04110 | RN70_04090 | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.954 |
AKS73160.1 | leuD | RN70_04110 | RN70_04085 | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.954 |
AKS73246.1 | AKS72624.1 | RN70_04560 | RN70_01150 | Pyruvate oxidase; Catalyzes the formation of acetyl phosphate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. | Lactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. | 0.912 |
AKS73246.1 | AKS73160.1 | RN70_04560 | RN70_04110 | Pyruvate oxidase; Catalyzes the formation of acetyl phosphate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.977 |
AKS73246.1 | ilvB | RN70_04560 | RN70_04115 | Pyruvate oxidase; Catalyzes the formation of acetyl phosphate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. | Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.850 |