| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKS73268.1 | relA | RN70_04830 | RN70_05785 | Exopolyphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.925 |
| AKS73268.1 | relQ | RN70_04830 | RN70_09265 | Exopolyphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | GTP pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.900 |
| dtd | lytH | RN70_05790 | RN70_05795 | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | Cell wall amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.863 |
| dtd | relA | RN70_05790 | RN70_05785 | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.914 |
| gmk | ndk | RN70_08275 | RN70_06570 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.932 |
| gmk | nrdE | RN70_08275 | RN70_10345 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.913 |
| gmk | nrdF | RN70_08275 | RN70_10340 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Ribonucleotide-diphosphate reductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.909 |
| gmk | pykA | RN70_08275 | RN70_05535 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.944 |
| gmk | relA | RN70_08275 | RN70_05785 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.922 |
| lytH | dtd | RN70_05795 | RN70_05790 | Cell wall amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | 0.863 |
| lytH | relA | RN70_05795 | RN70_05785 | Cell wall amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.860 |
| ndk | gmk | RN70_06570 | RN70_08275 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.932 |
| ndk | nrdD | RN70_06570 | RN70_01690 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Ribonucleoside-triphosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.912 |
| ndk | nrdE | RN70_06570 | RN70_10345 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.917 |
| ndk | nrdF | RN70_06570 | RN70_10340 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Ribonucleotide-diphosphate reductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.913 |
| ndk | pykA | RN70_06570 | RN70_05535 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.912 |
| ndk | relA | RN70_06570 | RN70_05785 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.916 |
| ndk | relQ | RN70_06570 | RN70_09265 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | GTP pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.900 |
| nrdD | ndk | RN70_01690 | RN70_06570 | Ribonucleoside-triphosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.912 |
| nrdD | nrdE | RN70_01690 | RN70_10345 | Ribonucleoside-triphosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.407 |
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