gmk protein (Staphylococcus schleiferi) - STRING interaction network

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Score

gmk

Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa)

Predicted Functional Partners:

rpoZ

0.995

guaA

0.971

xprT

0.950

pykA

0.944

apt

0.942

AKS74469.1

0.933

ndk

0.932

relA

0.922

AKS74423.1

0.915

guaC

0.914

Your Current Organism:

Staphylococcus schleiferi

NCBI taxonomy Id: 1295
Other names: ATCC 43808, CCUG 25351, CIP 103643, DSM 4807, LMG 13347, LMG:13347, NCTC 12218, NRRL B-14775, S. schleiferi, strain N850274

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKS74423.1	gmk	RN70_11175	RN70_08275	Deoxyguanosine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.915
AKS74469.1	apt	RN70_11510	RN70_05780	Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.928
AKS74469.1	gmk	RN70_11510	RN70_08275	Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.933
AKS74469.1	guaA	RN70_11510	RN70_12025	Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.963
AKS74469.1	guaC	RN70_11510	RN70_07410	Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Guanosine 5'-monophosphate oxidoreductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.	0.914
AKS74469.1	xprT	RN70_11510	RN70_12040	Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.	0.956
apt	AKS74469.1	RN70_05780	RN70_11510	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.928
apt	gmk	RN70_05780	RN70_08275	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.942
apt	guaA	RN70_05780	RN70_12025	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.981
apt	guaC	RN70_05780	RN70_07410	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Guanosine 5'-monophosphate oxidoreductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.	0.923
apt	relA	RN70_05780	RN70_05785	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.752
apt	xprT	RN70_05780	RN70_12040	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.	0.919
gmk	AKS74423.1	RN70_08275	RN70_11175	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Deoxyguanosine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.915
gmk	AKS74469.1	RN70_08275	RN70_11510	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.933
gmk	apt	RN70_08275	RN70_05780	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.942
gmk	guaA	RN70_08275	RN70_12025	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.971
gmk	guaC	RN70_08275	RN70_07410	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Guanosine 5'-monophosphate oxidoreductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.	0.914
gmk	ndk	RN70_08275	RN70_06570	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.932
gmk	pykA	RN70_08275	RN70_05535	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.944
gmk	relA	RN70_08275	RN70_05785	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.922