murI protein (Staphylococcus schleiferi) - STRING interaction network

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Score

murI

Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (268 aa)

Predicted Functional Partners:

AKS73934.1

0.986

murD

0.976

purQ

0.900

AKS73933.1

0.863

sdhC

0.738

sdhA

0.632

gltB

0.622

sdhB

0.598

murB

0.577

murF

0.561

Your Current Organism:

Staphylococcus schleiferi

NCBI taxonomy Id: 1295
Other names: ATCC 43808, CCUG 25351, CIP 103643, DSM 4807, LMG 13347, LMG:13347, NCTC 12218, NRRL B-14775, S. schleiferi, strain N850274

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKS73933.1	AKS73934.1	RN70_08485	RN70_08490	Phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.957
AKS73933.1	murI	RN70_08485	RN70_08495	Phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.	0.863
AKS73933.1	sdhA	RN70_08485	RN70_08505	Phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.684
AKS73933.1	sdhB	RN70_08485	RN70_08500	Phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.683
AKS73933.1	sdhC	RN70_08485	RN70_08510	Phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.738
AKS73934.1	AKS73933.1	RN70_08490	RN70_08485	Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	Phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.957
AKS73934.1	murI	RN70_08490	RN70_08495	Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.	0.986
AKS73934.1	sdhA	RN70_08490	RN70_08505	Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	Part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.675
AKS73934.1	sdhB	RN70_08490	RN70_08500	Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	Part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.675
AKS73934.1	sdhC	RN70_08490	RN70_08510	Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.738
gltB	murD	RN70_11745	RN70_08435	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.	0.475
gltB	murI	RN70_11745	RN70_08495	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.	0.622
gltB	purQ	RN70_11745	RN70_08860	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...]	0.900
gltB	sdhA	RN70_11745	RN70_08505	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.551
gltB	sdhC	RN70_11745	RN70_08510	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.538
murB	murD	RN70_10330	RN70_08435	UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation.	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.	0.673
murB	murF	RN70_10330	RN70_03980	UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation.	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily.	0.804
murB	murI	RN70_10330	RN70_08495	UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation.	Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.	0.577
murD	gltB	RN70_08435	RN70_11745	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.475
murD	murB	RN70_08435	RN70_10330	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.	UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation.	0.673