typA protein (Staphylococcus schleiferi) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

typA

GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology. (616 aa)

Predicted Functional Partners:

AKS73969.1

0.800

guaA

0.710

gltB

0.625

engA

0.623

tsf

0.600

rplA

0.587

cshB

0.561

AKS73140.1

0.550

infC

0.544

tig

0.532

Your Current Organism:

Staphylococcus schleiferi

NCBI taxonomy Id: 1295
Other names: ATCC 43808, CCUG 25351, CIP 103643, DSM 4807, LMG 13347, LMG:13347, NCTC 12218, NRRL B-14775, S. schleiferi, strain N850274

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKS73140.1	rplA	RN70_03985	RN70_11275	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.	50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.	0.573
AKS73140.1	typA	RN70_03985	RN70_08665	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family.	GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.550
AKS73969.1	typA	RN70_08670	RN70_08665	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.800
cshB	rplA	RN70_06145	RN70_11275	DEAD/DEAH box helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures.	50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.	0.573
cshB	typA	RN70_06145	RN70_08665	DEAD/DEAH box helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures.	GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.561
engA	guaA	RN70_06540	RN70_12025	GTP-binding protein Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.571
engA	rplA	RN70_06540	RN70_11275	GTP-binding protein Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.	0.546
engA	typA	RN70_06540	RN70_08665	GTP-binding protein Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.623
gltB	guaA	RN70_11745	RN70_12025	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.842
gltB	typA	RN70_11745	RN70_08665	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.625
guaA	engA	RN70_12025	RN70_06540	GMP synthase; Catalyzes the synthesis of GMP from XMP.	GTP-binding protein Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	0.571
guaA	gltB	RN70_12025	RN70_11745	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.842
guaA	infC	RN70_12025	RN70_05605	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.	0.448
guaA	rplA	RN70_12025	RN70_11275	GMP synthase; Catalyzes the synthesis of GMP from XMP.	50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.	0.971
guaA	tig	RN70_12025	RN70_05630	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.	0.519
guaA	tsf	RN70_12025	RN70_08020	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.	0.591
guaA	typA	RN70_12025	RN70_08665	GMP synthase; Catalyzes the synthesis of GMP from XMP.	GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.710
infC	guaA	RN70_05605	RN70_12025	Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.448
infC	rplA	RN70_05605	RN70_11275	Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.	50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.	0.831
infC	tig	RN70_05605	RN70_05630	Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.	Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.	0.724

page 1 of 3

Server load: low (36%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About