| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKS72674.1 | fmtA | RN70_01420 | RN70_10070 | Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methicillin resistance protein FmtA; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.503 |
| AKS73387.1 | engA | RN70_05515 | RN70_06540 | Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | GTP-binding protein Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 0.516 |
| AKS73387.1 | fmtA | RN70_05515 | RN70_10070 | Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methicillin resistance protein FmtA; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.539 |
| AKS74029.1 | fmtA | RN70_08985 | RN70_10070 | Phosphoglucomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methicillin resistance protein FmtA; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.590 |
| AKS74619.1 | dltA | RN70_00720 | RN70_09140 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ATP-dependent AMP-binding enzyme family. | Alanine-phosphoribitol ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent A [...] | 0.490 |
| AKS74619.1 | dltB | RN70_00720 | RN70_09145 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ATP-dependent AMP-binding enzyme family. | D-alanine transfer protein DltB; Could be involved in the transport of activated D-alanine through the membrane. | 0.838 |
| AKS74619.1 | dltC | RN70_00720 | RN70_09150 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ATP-dependent AMP-binding enzyme family. | Alanine-phosphoribitol ligase; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.957 |
| AKS74619.1 | dltD | RN70_00720 | RN70_09155 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ATP-dependent AMP-binding enzyme family. | DltD; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.785 |
| AKS74619.1 | fmtA | RN70_00720 | RN70_10070 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ATP-dependent AMP-binding enzyme family. | Methicillin resistance protein FmtA; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.623 |
| dltA | AKS74619.1 | RN70_09140 | RN70_00720 | Alanine-phosphoribitol ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent A [...] | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.490 |
| dltA | dltB | RN70_09140 | RN70_09145 | Alanine-phosphoribitol ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent A [...] | D-alanine transfer protein DltB; Could be involved in the transport of activated D-alanine through the membrane. | 0.996 |
| dltA | dltC | RN70_09140 | RN70_09150 | Alanine-phosphoribitol ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent A [...] | Alanine-phosphoribitol ligase; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.999 |
| dltA | dltD | RN70_09140 | RN70_09155 | Alanine-phosphoribitol ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent A [...] | DltD; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
| dltA | fmtA | RN70_09140 | RN70_10070 | Alanine-phosphoribitol ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent A [...] | Methicillin resistance protein FmtA; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.550 |
| dltA | fmtC | RN70_09140 | RN70_07295 | Alanine-phosphoribitol ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent A [...] | Phosphatidylglycerol lysyltransferase; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | 0.540 |
| dltB | AKS74619.1 | RN70_09145 | RN70_00720 | D-alanine transfer protein DltB; Could be involved in the transport of activated D-alanine through the membrane. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.838 |
| dltB | dltA | RN70_09145 | RN70_09140 | D-alanine transfer protein DltB; Could be involved in the transport of activated D-alanine through the membrane. | Alanine-phosphoribitol ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent A [...] | 0.996 |
| dltB | dltC | RN70_09145 | RN70_09150 | D-alanine transfer protein DltB; Could be involved in the transport of activated D-alanine through the membrane. | Alanine-phosphoribitol ligase; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.998 |
| dltB | dltD | RN70_09145 | RN70_09155 | D-alanine transfer protein DltB; Could be involved in the transport of activated D-alanine through the membrane. | DltD; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
| dltB | fmtA | RN70_09145 | RN70_10070 | D-alanine transfer protein DltB; Could be involved in the transport of activated D-alanine through the membrane. | Methicillin resistance protein FmtA; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.674 |
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