ALP94417.1 protein (Intestinimonas butyriciproducens)

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

ALP94417.1

Multi antimicrobial extrusion protein (Na(+)/drug antiporter). (457 aa)

Predicted Functional Partners:

coaX-3

0.705

ALP93795.1

0.630

ALP94419.1

0.612

ALP92751.1

0.509

ALP92473.1

0.494

ALP92775.1

0.454

ALP94420.1

0.436

Your Current Organism:

Intestinimonas butyriciproducens

NCBI taxonomy Id: 1297617
Other names: CCUG 63529, Candidatus Clostridium anorexicus, DSM 26588, I. butyriciproducens, Intestinimonas butyriciproducens Klaring et al. 2013, Pseudoflavonifractor sp. 2-1.1, Pseudoflavonifractor sp. SRB-521-5-I, strain SRB-521-5-I

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALP92473.1	ALP92751.1	IB211_00077c	IB211_00356	Na+-driven multidrug efflux pump.	PAP2 family protein.	0.509
ALP92473.1	ALP92775.1	IB211_00077c	IB211_00380c	Na+-driven multidrug efflux pump.	D-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.	0.454
ALP92473.1	ALP94417.1	IB211_00077c	IB211_02026c	Na+-driven multidrug efflux pump.	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	0.494
ALP92751.1	ALP92473.1	IB211_00356	IB211_00077c	PAP2 family protein.	Na+-driven multidrug efflux pump.	0.509
ALP92751.1	ALP92775.1	IB211_00356	IB211_00380c	PAP2 family protein.	D-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.	0.762
ALP92751.1	ALP93795.1	IB211_00356	IB211_01402	PAP2 family protein.	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	0.509
ALP92751.1	ALP94417.1	IB211_00356	IB211_02026c	PAP2 family protein.	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	0.509
ALP92775.1	ALP92473.1	IB211_00380c	IB211_00077c	D-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.	Na+-driven multidrug efflux pump.	0.454
ALP92775.1	ALP92751.1	IB211_00380c	IB211_00356	D-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.	PAP2 family protein.	0.762
ALP92775.1	ALP93795.1	IB211_00380c	IB211_01402	D-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	0.454
ALP92775.1	ALP94417.1	IB211_00380c	IB211_02026c	D-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	0.454
ALP93795.1	ALP92751.1	IB211_01402	IB211_00356	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	PAP2 family protein.	0.509
ALP93795.1	ALP92775.1	IB211_01402	IB211_00380c	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	D-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.	0.454
ALP93795.1	ALP94417.1	IB211_01402	IB211_02026c	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	0.630
ALP94417.1	ALP92473.1	IB211_02026c	IB211_00077c	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	Na+-driven multidrug efflux pump.	0.494
ALP94417.1	ALP92751.1	IB211_02026c	IB211_00356	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	PAP2 family protein.	0.509
ALP94417.1	ALP92775.1	IB211_02026c	IB211_00380c	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	D-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.	0.454
ALP94417.1	ALP93795.1	IB211_02026c	IB211_01402	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	0.630
ALP94417.1	ALP94419.1	IB211_02026c	IB211_02028c	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	Phosphoesterase.	0.612
ALP94417.1	ALP94420.1	IB211_02026c	IB211_02029	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	Hypothetical protein.	0.436

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.831

expected number of edges:

11

PPI enrichment p-value:

0.00661

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055085

Transmembrane transport

9 of 245

0.89

0.83

8.52e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

9 of 387

0.69

0.58

0.00044

GO:0016020

Membrane

10 of 698

0.48

0.38

0.0017

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2672

Mixed, incl. ABC transporter, CbiO/EcfA subunit, and Cobalt transport protein

9 of 30

1.8

4.17

5.62e-13

CL:2670

Mixed, incl. Cobalt transport protein, and ABC transporter, CbiO/EcfA subunit

10 of 51

1.61

3.48

4.16e-13

CL:2722

Mixed, incl. Tricarboxylic acid biosynthetic process, and ABC transporter, CbiO/EcfA subunit

4 of 5

2.22

2.84

2.22e-06

CL:2668

Mixed, incl. ABC transporters, and DNA-binding HTH domain, TetR-type

11 of 111

1.32

2.33

7.15e-13

CL:2673

Mixed, incl. ABC transporter, CbiO/EcfA subunit, and Cobalt transport protein

5 of 25

1.62

2.06

6.47e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

10 of 194

1.03

1.28

2.46e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0043190

ATP-binding cassette (ABC) transporter complex

7 of 34

1.64

2.71

1.96e-08

GOCC:0005886

Plasma membrane

9 of 242

0.89

0.94

1.77e-06

GOCC:0032991

Protein-containing complex

8 of 382

0.64

0.52

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0067

ATP-binding

6 of 228

0.74

0.41

0.0483

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR015856

ABC transporter, CbiO/EcfA subunit

6 of 10

2.1

3.62

1.55e-08

IPR017871

ABC transporter-like, conserved site

6 of 72

1.24

1.21

0.00022

IPR003439

ABC transporter-like, ATP-binding domain

6 of 90

1.15

1.04

0.00051

IPR003593

AAA+ ATPase domain

6 of 111

1.05

0.88

0.0012

IPR027417

P-loop containing nucleoside triphosphate hydrolase

6 of 224

0.75

0.41

0.0492

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

6 of 109

1.06

0.97

0.00040

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