ALP95309.1 protein (Intestinimonas butyriciproducens)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ALP95309.1

Na+ driven multidrug efflux pump. (466 aa)

Predicted Functional Partners:

ALP95310.1

0.778

ALP95311.1

0.773

ALP92473.1

0.730

ALP93747.1

0.684

ALP93043.1

0.618

ALP93773.1

0.611

ALP95312.1

0.572

ALP95308.1

0.512

ALP92751.1

0.509

ALP94040.1

0.500

Your Current Organism:

Intestinimonas butyriciproducens

NCBI taxonomy Id: 1297617
Other names: CCUG 63529, Candidatus Clostridium anorexicus, DSM 26588, I. butyriciproducens, Intestinimonas butyriciproducens Klaring et al. 2013, Pseudoflavonifractor sp. 2-1.1, Pseudoflavonifractor sp. SRB-521-5-I, strain SRB-521-5-I

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALP92473.1	ALP92751.1	IB211_00077c	IB211_00356	Na+-driven multidrug efflux pump.	PAP2 family protein.	0.509
ALP92473.1	ALP93043.1	IB211_00077c	IB211_00648c	Na+-driven multidrug efflux pump.	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	0.458
ALP92473.1	ALP93747.1	IB211_00077c	IB211_01354c	Na+-driven multidrug efflux pump.	Na+-driven multidrug efflux pump.	0.429
ALP92473.1	ALP95309.1	IB211_00077c	IB211_02918c	Na+-driven multidrug efflux pump.	Na+ driven multidrug efflux pump.	0.730
ALP92751.1	ALP92473.1	IB211_00356	IB211_00077c	PAP2 family protein.	Na+-driven multidrug efflux pump.	0.509
ALP92751.1	ALP93043.1	IB211_00356	IB211_00648c	PAP2 family protein.	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	0.509
ALP92751.1	ALP93747.1	IB211_00356	IB211_01354c	PAP2 family protein.	Na+-driven multidrug efflux pump.	0.509
ALP92751.1	ALP93773.1	IB211_00356	IB211_01380c	PAP2 family protein.	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	0.509
ALP92751.1	ALP94040.1	IB211_00356	IB211_01649c	PAP2 family protein.	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	0.509
ALP92751.1	ALP95309.1	IB211_00356	IB211_02918c	PAP2 family protein.	Na+ driven multidrug efflux pump.	0.509
ALP93043.1	ALP92473.1	IB211_00648c	IB211_00077c	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	Na+-driven multidrug efflux pump.	0.458
ALP93043.1	ALP92751.1	IB211_00648c	IB211_00356	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	PAP2 family protein.	0.509
ALP93043.1	ALP95309.1	IB211_00648c	IB211_02918c	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	Na+ driven multidrug efflux pump.	0.618
ALP93747.1	ALP92473.1	IB211_01354c	IB211_00077c	Na+-driven multidrug efflux pump.	Na+-driven multidrug efflux pump.	0.429
ALP93747.1	ALP92751.1	IB211_01354c	IB211_00356	Na+-driven multidrug efflux pump.	PAP2 family protein.	0.509
ALP93747.1	ALP95309.1	IB211_01354c	IB211_02918c	Na+-driven multidrug efflux pump.	Na+ driven multidrug efflux pump.	0.684
ALP93773.1	ALP92751.1	IB211_01380c	IB211_00356	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	PAP2 family protein.	0.509
ALP93773.1	ALP95309.1	IB211_01380c	IB211_02918c	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	Na+ driven multidrug efflux pump.	0.611
ALP94040.1	ALP92751.1	IB211_01649c	IB211_00356	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	PAP2 family protein.	0.509
ALP94040.1	ALP95309.1	IB211_01649c	IB211_02918c	Multi antimicrobial extrusion protein (Na(+)/drug antiporter).	Na+ driven multidrug efflux pump.	0.500

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.936

expected number of edges:

12

PPI enrichment p-value:

2.2e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0072318

Clathrin coat disassembly

3 of 8

2.82

2.23

8.39e-05

GO:0007175

Negative regulation of epidermal growth factor-activated receptor activity

3 of 11

2.68

2.21

8.39e-05

GO:0048488

Synaptic vesicle endocytosis

4 of 40

2.24

2.11

8.39e-05

GO:0061097

Regulation of protein tyrosine kinase activity

4 of 73

1.98

1.97

9.58e-05

GO:0001933

Negative regulation of protein phosphorylation

5 of 225

1.59

1.66

0.00011

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0047690

Aspartyltransferase activity

3 of 3

3.24

2.81

8.25e-06

GO:0001784

Phosphotyrosine residue binding

4 of 45

2.19

2.41

1.79e-05

GO:0017124

SH3 domain binding

4 of 84

1.92

1.98

7.77e-05

GO:0030971

Receptor tyrosine kinase binding

3 of 66

1.9

1.35

0.0021

GO:0019900

Kinase binding

6 of 583

1.26

1.27

0.00014

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045121

Membrane raft

5 of 192

1.66

1.79

7.07e-05

GO:0098793

Presynapse

5 of 347

1.4

1.31

0.00042

GO:0030054

Cell junction

7 of 1473

0.92

0.75

0.0015

GO:0098978

Glutamatergic synapse

3 of 206

1.41

0.73

0.0270

GO:0031982

Vesicle

7 of 1679

0.86

0.67

0.0028

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14675

Mixed, incl. Adaptor protein Cbl, and Sprouty

5 of 12

2.86

4.96

5.50e-10

CL:14678

Synaptic vesicle uncoating, and Adaptor protein Cbl

4 of 6

3.07

4.15

2.58e-08

CL:14423

PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, and Transmembrane receptor protein tyrosine kinase signaling pathway

6 of 138

1.88

3.01

9.96e-08

CL:20137

Mixed, incl. Clathrin-coated pit, and ENTH domain

3 of 50

2.02

1.33

0.0027

CL:20227

Repeat in HS1/Cortactin, and Dynamin GTPase effector domain

2 of 5

2.85

1.3

0.0045

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

oro04144

Endocytosis

8 of 243

1.76

3.66

3.81e-11

oro04012

ErbB signaling pathway

4 of 83

1.93

2.22

2.04e-05

oro04072

Phospholipase D signaling pathway

4 of 150

1.67

1.69

0.00014

oro04120

Ubiquitin mediated proteolysis

4 of 158

1.65

1.68

0.00014

oro05100

Bacterial invasion of epithelial cells

3 of 76

1.84

1.53

0.00070

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8856828

Clathrin-mediated endocytosis

7 of 188

1.82

3.27

5.16e-09

MAP-437239

Recycling pathway of L1

4 of 25

2.45

3.1

1.14e-06

MAP-182971

EGFR downregulation

4 of 35

2.3

2.86

2.62e-06

MAP-373760

L1CAM interactions

4 of 62

2.05

2.34

1.71e-05

MAP-177929

Signaling by EGFR

4 of 63

2.05

2.33

1.71e-05

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02761

CBL proto-oncogene N-terminus, EF hand-like domain

3 of 3

3.24

2.88

6.29e-06

PF02262

CBL proto-oncogene N-terminal domain 1

3 of 3

3.24

2.88

6.29e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036537

Adaptor protein Cbl, N-terminal domain superfamily

3 of 3

3.24

2.64

1.67e-05

IPR024162

Adaptor protein Cbl

3 of 3

3.24

2.64

1.67e-05

IPR024159

Adaptor protein Cbl, PTB domain

3 of 3

3.24

2.64

1.67e-05

IPR014742

Adaptor protein Cbl, SH2-like domain

3 of 3

3.24

2.64

1.67e-05

IPR014741

Adaptor protein Cbl, EF hand-like

3 of 3

3.24

2.64

1.67e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00302

Dynamin GTPase effector domain

2 of 6

2.77

1.2

0.0067

SM00053

Dynamin, GTPase

2 of 7

2.7

1.2

0.0067

SM00721

BAR

2 of 13

2.43

1.13

0.0083

SM00165

Ubiquitin associated domain

2 of 32

2.04

0.79

0.0332

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