ALP95635.1 protein (Intestinimonas butyriciproducens)

Nodes:

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

ALP95635.1

Hypothetical protein. (198 aa)

Predicted Functional Partners:

ALP95634.1

0.581

ALP95636.1

0.559

ALP95633.1

0.467

Your Current Organism:

Intestinimonas butyriciproducens

NCBI taxonomy Id: 1297617
Other names: CCUG 63529, Candidatus Clostridium anorexicus, DSM 26588, I. butyriciproducens, Intestinimonas butyriciproducens Klaring et al. 2013, Pseudoflavonifractor sp. 2-1.1, Pseudoflavonifractor sp. SRB-521-5-I, strain SRB-521-5-I

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALP95633.1	ALP95634.1	IB211_03243c	IB211_03244c	Hypothetical protein.	Hypothetical protein.	0.610
ALP95633.1	ALP95635.1	IB211_03243c	IB211_03245c	Hypothetical protein.	Hypothetical protein.	0.467
ALP95634.1	ALP95633.1	IB211_03244c	IB211_03243c	Hypothetical protein.	Hypothetical protein.	0.610
ALP95634.1	ALP95635.1	IB211_03244c	IB211_03245c	Hypothetical protein.	Hypothetical protein.	0.581
ALP95634.1	ALP95636.1	IB211_03244c	IB211_03246c	Hypothetical protein.	Pyruvate,phosphate dikinase; Belongs to the PEP-utilizing enzyme family.	0.432
ALP95635.1	ALP95633.1	IB211_03245c	IB211_03243c	Hypothetical protein.	Hypothetical protein.	0.467
ALP95635.1	ALP95634.1	IB211_03245c	IB211_03244c	Hypothetical protein.	Hypothetical protein.	0.581
ALP95635.1	ALP95636.1	IB211_03245c	IB211_03246c	Hypothetical protein.	Pyruvate,phosphate dikinase; Belongs to the PEP-utilizing enzyme family.	0.559
ALP95636.1	ALP95634.1	IB211_03246c	IB211_03244c	Pyruvate,phosphate dikinase; Belongs to the PEP-utilizing enzyme family.	Hypothetical protein.	0.432
ALP95636.1	ALP95635.1	IB211_03246c	IB211_03245c	Pyruvate,phosphate dikinase; Belongs to the PEP-utilizing enzyme family.	Hypothetical protein.	0.559

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.982

expected number of edges:

14

PPI enrichment p-value:

1.87e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030216

Keratinocyte differentiation

4 of 69

2.03

1.79

0.00028

GO:0043588

Skin development

5 of 156

1.77

1.76

0.00015

GO:0006672

Ceramide metabolic process

4 of 86

1.93

1.66

0.00043

GO:0031424

Keratinization

3 of 28

2.29

1.57

0.0011

GO:0046513

Ceramide biosynthetic process

3 of 51

2.03

1.29

0.0032

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28815464

(2018) Inherited Nonsyndromic Ichthyoses: An Update on Pathophysiology, Diagnosis and Treatment.

8 of 12

3.09

9.46

1.74e-18

PMID:31833240

(2020) Targeted regions sequencing identified four novel PNPLA1 mutations in two Chinese families with autosomal recessive congenital ichthyosis.

8 of 26

2.75

8.13

1.25e-16

PMID:28249031

(2017) A de novo variant in the ASPRV1 gene in a dog with ichthyosis.

6 of 11

3.0

6.41

1.16e-12

PMID:28122049

(2017) A Defect in NIPAL4 Is Associated with Autosomal Recessive Congenital Ichthyosis in American Bulldogs.

6 of 12

2.96

6.36

1.30e-12

PMID:34599683

(2021) A frameshift insertion in FA2H causes a recessively inherited form of ichthyosis congenita in Chianina cattle.

5 of 8

3.06

5.22

2.44e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:33340

Mixed, incl. Magnesium ion transmembrane transport, and Keratinization

7 of 10

3.11

8.57

1.06e-16

CL:33344

Mixed, incl. Keratinization, and Apolipoprotein A-I receptor binding

5 of 5

3.26

6.13

6.22e-12

CL:13676

Mixed, incl. Winged helix Storkhead-box1 domain, and Hemimethylated DNA-binding protein YccV like

2 of 6

2.79

1.33

0.0038

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