CUS47760.1 protein (Idiomarinaceae bacterium HL53)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CUS47760.1

Imidazolonepropionase. (448 aa)

Predicted Functional Partners:

CUS47761.1

0.773

CUS47346.1

0.766

hutU

0.760

phaG

0.727

phaF

0.727

phaE

0.727

phaD

0.727

phaC

0.727

phaA

0.727

CUS47602.1

0.704

Your Current Organism:

Idiomarinaceae bacterium HL53

NCBI taxonomy Id: 1298881
Other names: I. bacterium HL-53, Idiomarina sp. HL-53, Idiomarinaceae bacterium HL-53

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUS47346.1	CUS47602.1	Ga0003345_0272	Ga0003345_0535	Amidohydrolase family protein.	Zinc carboxypeptidase.	0.452
CUS47346.1	CUS47760.1	Ga0003345_0272	Ga0003345_0694	Amidohydrolase family protein.	Imidazolonepropionase.	0.766
CUS47346.1	hutU	Ga0003345_0272	Ga0003345_0884	Amidohydrolase family protein.	Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate.	0.760
CUS47602.1	CUS47346.1	Ga0003345_0535	Ga0003345_0272	Zinc carboxypeptidase.	Amidohydrolase family protein.	0.452
CUS47602.1	CUS47760.1	Ga0003345_0535	Ga0003345_0694	Zinc carboxypeptidase.	Imidazolonepropionase.	0.704
CUS47760.1	CUS47346.1	Ga0003345_0694	Ga0003345_0272	Imidazolonepropionase.	Amidohydrolase family protein.	0.766
CUS47760.1	CUS47602.1	Ga0003345_0694	Ga0003345_0535	Imidazolonepropionase.	Zinc carboxypeptidase.	0.704
CUS47760.1	CUS47761.1	Ga0003345_0694	Ga0003345_0695	Imidazolonepropionase.	Voltage-gated sodium channel.	0.773
CUS47760.1	hutU	Ga0003345_0694	Ga0003345_0884	Imidazolonepropionase.	Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate.	0.760
CUS47760.1	phaA	Ga0003345_0694	Ga0003345_0701	Imidazolonepropionase.	Multisubunit potassium/proton antiporter, PhaA subunit (TC 2.A.63.1.1)/multisubunit potassium/proton antiporter, PhaB subunit (TC 2.A.63.1.1).	0.727
CUS47760.1	phaC	Ga0003345_0694	Ga0003345_0700	Imidazolonepropionase.	Multisubunit potassium/proton antiporter, PhaC subunit.	0.727
CUS47760.1	phaD	Ga0003345_0694	Ga0003345_0699	Imidazolonepropionase.	Multisubunit potassium/proton antiporter, PhaD subunit (TC 2.A.63.1.1).	0.727
CUS47760.1	phaE	Ga0003345_0694	Ga0003345_0698	Imidazolonepropionase.	Multisubunit potassium/proton antiporter, PhaE subunit (TC 2.A.63.1.1).	0.727
CUS47760.1	phaF	Ga0003345_0694	Ga0003345_0697	Imidazolonepropionase.	Multisubunit potassium/proton antiporter, PhaF subunit.	0.727
CUS47760.1	phaG	Ga0003345_0694	Ga0003345_0696	Imidazolonepropionase.	Multisubunit potassium/proton antiporter, PhaG subunit (TC 2.A.63.1.1).	0.727
CUS47761.1	CUS47760.1	Ga0003345_0695	Ga0003345_0694	Voltage-gated sodium channel.	Imidazolonepropionase.	0.773
CUS47761.1	phaA	Ga0003345_0695	Ga0003345_0701	Voltage-gated sodium channel.	Multisubunit potassium/proton antiporter, PhaA subunit (TC 2.A.63.1.1)/multisubunit potassium/proton antiporter, PhaB subunit (TC 2.A.63.1.1).	0.732
CUS47761.1	phaC	Ga0003345_0695	Ga0003345_0700	Voltage-gated sodium channel.	Multisubunit potassium/proton antiporter, PhaC subunit.	0.731
CUS47761.1	phaD	Ga0003345_0695	Ga0003345_0699	Voltage-gated sodium channel.	Multisubunit potassium/proton antiporter, PhaD subunit (TC 2.A.63.1.1).	0.728
CUS47761.1	phaE	Ga0003345_0695	Ga0003345_0698	Voltage-gated sodium channel.	Multisubunit potassium/proton antiporter, PhaE subunit (TC 2.A.63.1.1).	0.732

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.856

expected number of edges:

18

PPI enrichment p-value:

0.0139

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032508

DNA duplex unwinding

4 of 51

2.01

1.8

0.00026

GO:0000723

Telomere maintenance

3 of 36

2.04

1.42

0.0018

GO:0070199

Establishment of protein localization to chromosome

2 of 6

2.64

1.35

0.0035

GO:0007004

Telomere maintenance via telomerase

2 of 5

2.72

1.35

0.0035

GO:2000573

Positive regulation of DNA biosynthetic process

2 of 9

2.47

1.25

0.0051

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043047

Single-stranded telomeric DNA binding

2 of 4

2.82

1.21

0.0063

GO:0140097

Catalytic activity, acting on DNA

4 of 151

1.54

1.02

0.0063

GO:0009982

Pseudouridine synthase activity

2 of 10

2.42

1.01

0.0139

GO:0008094

ATP-dependent activity, acting on DNA

3 of 88

1.65

0.91

0.0139

GO:0004520

Endodeoxyribonuclease activity

2 of 21

2.1

0.88

0.0227

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030870

Mre11 complex

2 of 2

3.12

1.41

0.0029

GO:0005694

Chromosome

5 of 360

1.26

0.97

0.0029

GO:0005657

Replication fork

2 of 27

1.99

0.82

0.0280

GO:0043232

Intracellular non-membrane-bounded organelle

7 of 1612

0.76

0.5

0.0145

GO:0070013

Intracellular organelle lumen

5 of 993

0.82

0.46

0.0427

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5386

Homologous DNA Pairing and Strand Exchange, and Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

3 of 20

2.3

1.89

0.00026

CL:5382

HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), and DNA polymerase complex

4 of 60

1.94

1.81

0.00021

CL:5399

Sensing of DNA Double Strand Breaks, and D-loop DNA binding

2 of 5

2.72

1.48

0.0020

CL:7848

Box H/ACA RNP complex, and Box H/ACA snoRNP assembly

2 of 6

2.64

1.42

0.0025

CL:4172

Protein palmitoylation, and Telomere assembly

2 of 11

2.38

1.19

0.0063

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03450

Non-homologous end-joining

2 of 12

2.34

1.16

0.0072

map03440

Homologous recombination

2 of 54

1.69

0.67

0.0496

map03030

DNA replication

2 of 49

1.73

0.67

0.0496

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5685938

HDR through Single Strand Annealing (SSA)

4 of 26

2.31

2.7

5.73e-06

MAP-180786

Extension of Telomeres

4 of 28

2.28

2.68

5.73e-06

MAP-157579

Telomere Maintenance

4 of 35

2.18

2.63

5.73e-06

MAP-5693607

Processing of DNA double-strand break ends

4 of 36

2.17

2.62

5.73e-06

MAP-5685942

HDR through Homologous Recombination (HRR)

4 of 39

2.13

2.6

5.73e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030870

Mre11 complex

2 of 5

2.72

1.09

0.0106

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (12%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About