STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAN3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exo [...] (557 aa)    
Predicted Functional Partners:
PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...]
  
 
 0.999
J056_002442
Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.
    
 0.972
J056_000437
RNA exonuclease 4.
    
 0.810
J056_003537
Exonuclease domain-containing protein.
    
 0.810
J056_002172
Exonuclease GOR.
    
 0.810
J056_001425
Polyadenylate-binding protein, cytoplasmic and nuclear.
    
 0.721
J056_004630
Polyadenylate-binding protein, cytoplasmic and nuclear.
    
 0.721
J056_003640
Glucose-repressible alcohol dehydrogenase transcriptional effector.
   
 
 0.619
J056_002902
Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.
    
 0.605
J056_002031
ATP-dependent RNA helicase FAL1; Belongs to the DEAD box helicase family.
    
 0.604
Your Current Organism:
Wallemia ichthyophaga
NCBI taxonomy Id: 1299270
Other names: W. ichthyophaga EXF-994, Wallemia ichthyophaga EXF-994
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