Gasu_60070 protein (Galdieria sulphuraria) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

Gasu_60070

Fatty acid hydroxylase; Belongs to the sterol desaturase family. (269 aa)

Predicted Functional Partners:

Gasu_09900

0.816

Gasu_30550

0.788

Gasu_06490

0.721

Gasu_19640

0.721

Gasu_60260

0.664

Gasu_25030

0.652

Gasu_24370

0.628

Gasu_00950

0.609

Gasu_32640

0.609

Gasu_18960

0.576

Your Current Organism:

Galdieria sulphuraria

NCBI taxonomy Id: 130081
Other names: G. sulphuraria, SAG 17.91

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Gasu_00950	Gasu_06490	M2X845	M2X6V3	Farnesyl-diphosphate farnesyltransferase.	Cytochrome P45, family 51 (Sterol 14-demethylase); Belongs to the cytochrome P450 family.	0.816
Gasu_00950	Gasu_09900	M2X845	M2X615	Farnesyl-diphosphate farnesyltransferase.	C-5 sterol desaturase; Belongs to the sterol desaturase family.	0.892
Gasu_00950	Gasu_18960	M2X845	M2Y4M1	Farnesyl-diphosphate farnesyltransferase.	Delta14-sterol reductase.	0.609
Gasu_00950	Gasu_19640	M2X845	M2Y4F8	Farnesyl-diphosphate farnesyltransferase.	Cytochrome P45, family 39, subfamily A (24-hydroxycholesterol7alpha-hydroxylase); Belongs to the cytochrome P450 family.	0.760
Gasu_00950	Gasu_24370	M2X845	M2X1R8	Farnesyl-diphosphate farnesyltransferase.	Putative ergosterol biosynthetic protein 28 isoform 2.	0.856
Gasu_00950	Gasu_25030	M2X845	M2XJ37	Farnesyl-diphosphate farnesyltransferase.	C-8 sterol isomerase.	0.526
Gasu_00950	Gasu_30550	M2X845	M2Y114	Farnesyl-diphosphate farnesyltransferase.	Squalene monooxygenase.	0.974
Gasu_00950	Gasu_60070	M2X845	M2VT47	Farnesyl-diphosphate farnesyltransferase.	Fatty acid hydroxylase; Belongs to the sterol desaturase family.	0.609
Gasu_00950	Gasu_60260	M2X845	M2X975	Farnesyl-diphosphate farnesyltransferase.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.794
Gasu_06490	Gasu_00950	M2X6V3	M2X845	Cytochrome P45, family 51 (Sterol 14-demethylase); Belongs to the cytochrome P450 family.	Farnesyl-diphosphate farnesyltransferase.	0.816
Gasu_06490	Gasu_09900	M2X6V3	M2X615	Cytochrome P45, family 51 (Sterol 14-demethylase); Belongs to the cytochrome P450 family.	C-5 sterol desaturase; Belongs to the sterol desaturase family.	0.711
Gasu_06490	Gasu_18960	M2X6V3	M2Y4M1	Cytochrome P45, family 51 (Sterol 14-demethylase); Belongs to the cytochrome P450 family.	Delta14-sterol reductase.	0.976
Gasu_06490	Gasu_24370	M2X6V3	M2X1R8	Cytochrome P45, family 51 (Sterol 14-demethylase); Belongs to the cytochrome P450 family.	Putative ergosterol biosynthetic protein 28 isoform 2.	0.868
Gasu_06490	Gasu_25030	M2X6V3	M2XJ37	Cytochrome P45, family 51 (Sterol 14-demethylase); Belongs to the cytochrome P450 family.	C-8 sterol isomerase.	0.871
Gasu_06490	Gasu_30550	M2X6V3	M2Y114	Cytochrome P45, family 51 (Sterol 14-demethylase); Belongs to the cytochrome P450 family.	Squalene monooxygenase.	0.928
Gasu_06490	Gasu_32640	M2X6V3	M2Y038	Cytochrome P45, family 51 (Sterol 14-demethylase); Belongs to the cytochrome P450 family.	Phytoene synthase.	0.760
Gasu_06490	Gasu_60070	M2X6V3	M2VT47	Cytochrome P45, family 51 (Sterol 14-demethylase); Belongs to the cytochrome P450 family.	Fatty acid hydroxylase; Belongs to the sterol desaturase family.	0.721
Gasu_06490	Gasu_60260	M2X6V3	M2X975	Cytochrome P45, family 51 (Sterol 14-demethylase); Belongs to the cytochrome P450 family.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.923
Gasu_09900	Gasu_00950	M2X615	M2X845	C-5 sterol desaturase; Belongs to the sterol desaturase family.	Farnesyl-diphosphate farnesyltransferase.	0.892
Gasu_09900	Gasu_06490	M2X615	M2X6V3	C-5 sterol desaturase; Belongs to the sterol desaturase family.	Cytochrome P45, family 51 (Sterol 14-demethylase); Belongs to the cytochrome P450 family.	0.711

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Network Stats

number of nodes:

10

number of edges:

21

average node degree:

4.2

avg. local clustering coefficient:

0.873

expected number of edges:

9

PPI enrichment p-value:

0.000652

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0040019

Positive regulation of embryonic development

2 of 6

2.88

0.81

0.0391

GO:0045039

Protein insertion into mitochondrial inner membrane

2 of 8

2.76

0.8

0.0391

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005743

Mitochondrial inner membrane

4 of 419

1.34

0.72

0.0279

GO:0098798

Mitochondrial protein-containing complex

3 of 267

1.41

0.65

0.0463

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6513

Mixed, incl. Tim10-like, and Mitochondrial intermembrane space import and assembly protein 40

4 of 17

2.73

3.46

5.49e-07

CL:6519

TIM22 mitochondrial import inner membrane insertion complex, and Tim10-like

3 of 5

3.14

2.98

5.61e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 47

2.16

1.47

0.0019

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 5

2.96

1.46

0.0028

GOCC:0098798

Mitochondrial protein complex

4 of 228

1.6

1.2

0.0028

GOCC:0005740

Mitochondrial envelope

4 of 383

1.38

1.05

0.0034

GOCC:0031967

Organelle envelope

5 of 547

1.32

1.03

0.0028

GOCC:0071013

Catalytic step 2 spliceosome

2 of 37

2.09

0.92

0.0215

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 20

2.36

1.05

0.0132

KW-0496

Mitochondrion

3 of 160

1.63

0.94

0.0132

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10312

Conserved mid region of cactin

2 of 2

3.36

1.51

0.0023

PF04621

PEA3 subfamily ETS-domain transcription factor N terminal domain

2 of 4

3.06

1.45

0.0029

PF02953

Tim10/DDP family zinc finger

2 of 6

2.88

1.39

0.0036

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019134

Splicing factor Cactin, C-terminal

2 of 2

3.36

1.23

0.0073

IPR018816

Splicing factor cactin, central domain

2 of 2

3.36

1.23

0.0073

IPR006715

PEA3-type ETS-domain transcription factor, N-terminal

2 of 4

3.06

1.22

0.0073

IPR035427

Tim10-like domain superfamily

2 of 6

2.88

1.18

0.0085

IPR004217

Tim10-like

2 of 6

2.88

1.18

0.0085

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01050

Cactus-binding C-terminus of cactin protein

2 of 3

3.18

1.65

0.0013

SM00413

Erythroblast transformation specific domain

2 of 32

2.15

0.8

0.0372

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