Gasu_44480 protein (Galdieria sulphuraria) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

Gasu_44480

NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (316 aa)

Predicted Functional Partners:

Gasu_55380

0.913

Gasu_53720

0.910

Gasu_07330

0.903

Gasu_62320

0.731

Gasu_10200

0.731

Gasu_05920

0.670

Gasu_43430

0.628

Gasu_17700

0.628

Gasu_46810

0.620

Gasu_57360

0.600

Your Current Organism:

Galdieria sulphuraria

NCBI taxonomy Id: 130081
Other names: G. sulphuraria, SAG 17.91

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Gasu_05920	Gasu_07330	M2Y8L0	M2W810	Stearoyl-CoA desaturase (Delta-9 desaturase).	Cytochrome-b5 reductase.	0.670
Gasu_05920	Gasu_43430	M2Y8L0	M2XX21	Stearoyl-CoA desaturase (Delta-9 desaturase).	Orotidine-5'-phosphate decarboxylase isoform 2.	0.500
Gasu_05920	Gasu_44480	M2Y8L0	M2WVU7	Stearoyl-CoA desaturase (Delta-9 desaturase).	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.670
Gasu_05920	Gasu_53720	M2Y8L0	M2VV02	Stearoyl-CoA desaturase (Delta-9 desaturase).	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.670
Gasu_05920	Gasu_55380	M2Y8L0	M2VUK7	Stearoyl-CoA desaturase (Delta-9 desaturase).	Sulfite oxidase.	0.576
Gasu_07330	Gasu_05920	M2W810	M2Y8L0	Cytochrome-b5 reductase.	Stearoyl-CoA desaturase (Delta-9 desaturase).	0.670
Gasu_07330	Gasu_10200	M2W810	M2Y6H6	Cytochrome-b5 reductase.	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	0.731
Gasu_07330	Gasu_17700	M2W810	M2Y577	Cytochrome-b5 reductase.	Cytochrome b5; Belongs to the cytochrome b5 family.	0.677
Gasu_07330	Gasu_43430	M2W810	M2XX21	Cytochrome-b5 reductase.	Orotidine-5'-phosphate decarboxylase isoform 2.	0.628
Gasu_07330	Gasu_44480	M2W810	M2WVU7	Cytochrome-b5 reductase.	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.903
Gasu_07330	Gasu_46810	M2W810	M2XD40	Cytochrome-b5 reductase.	Ferredoxin-nitrite reductase.	0.536
Gasu_07330	Gasu_53720	M2W810	M2VV02	Cytochrome-b5 reductase.	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.910
Gasu_07330	Gasu_55380	M2W810	M2VUK7	Cytochrome-b5 reductase.	Sulfite oxidase.	0.913
Gasu_07330	Gasu_57360	M2W810	M2WS00	Cytochrome-b5 reductase.	Golgi transport protein GOT1-like protein.	0.600
Gasu_07330	Gasu_62320	M2W810	M2XR34	Cytochrome-b5 reductase.	Dihydroorotate oxidase.	0.731
Gasu_10200	Gasu_07330	M2Y6H6	M2W810	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	Cytochrome-b5 reductase.	0.731
Gasu_10200	Gasu_43430	M2Y6H6	M2XX21	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	Orotidine-5'-phosphate decarboxylase isoform 2.	0.991
Gasu_10200	Gasu_44480	M2Y6H6	M2WVU7	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.731
Gasu_10200	Gasu_53720	M2Y6H6	M2VV02	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.731
Gasu_10200	Gasu_57360	M2Y6H6	M2WS00	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	Golgi transport protein GOT1-like protein.	0.916

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Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.968

expected number of edges:

11

PPI enrichment p-value:

3.84e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006525

Arginine metabolic process

11 of 34

2.23

8.23

2.82e-21

GO:0006526

Arginine biosynthetic process

9 of 17

2.45

8.04

4.90e-18

GO:0006591

Ornithine metabolic process

4 of 6

2.55

3.56

1.65e-07

GO:0042450

Arginine biosynthetic process via ornithine

2 of 2

2.72

1.57

0.0014

GO:0044205

De novo UMP biosynthetic process

2 of 7

2.18

1.12

0.0079

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0103045

Methione N-acyltransferase activity

2 of 2

2.72

0.93

0.0203

GO:0004088

Carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

2 of 2

2.72

0.93

0.0203

GO:0004042

acetyl-CoA:L-glutamate N-acetyltransferase activity

2 of 2

2.72

0.93

0.0203

GO:0016774

Phosphotransferase activity, carboxyl group as acceptor

2 of 7

2.18

0.82

0.0303

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

3 of 51

1.49

0.73

0.0303

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1829

0.5

0.42

0.00052

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1505

Arginine biosynthesis, and Amino acid antiporter

9 of 15

2.5

8.22

4.37e-18

CL:1510

Arginine biosynthesis

6 of 6

2.72

6.12

1.70e-12

CL:1367

Cellular amino acid biosynthetic process, and Ribonucleoside monophosphate biosynthetic process

11 of 152

1.58

3.6

3.78e-15

CL:1525

Amino acid antiporter, and Arginine catabolic process to ornithine

2 of 5

2.33

1.03

0.0127

CL:1578

Pyrimidine biosynthesis, and Dihydroorotase, conserved site

2 of 6

2.25

0.99

0.0148

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pfn00220

Arginine biosynthesis

9 of 36

2.12

6.25

3.12e-16

pfn00250

Alanine, aspartate and glutamate metabolism

4 of 39

1.74

1.95

3.78e-05

pfn01230

Biosynthesis of amino acids

7 of 179

1.32

1.75

6.17e-07

pfn01210

2-Oxocarboxylic acid metabolism

4 of 51

1.62

1.75

6.84e-05

pfn01110

Biosynthesis of secondary metabolites

8 of 614

0.84

0.78

6.84e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005951

Carbamoyl-phosphate synthase complex

2 of 2

2.72

1.18

0.0073

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0055

Arginine biosynthesis

9 of 13

2.56

8.87

2.96e-19

KW-0963

Cytoplasm

8 of 311

1.13

1.38

8.14e-07

KW-0665

Pyrimidine biosynthesis

2 of 10

2.03

1.0

0.0124

KW-0436

Ligase

3 of 73

1.34

0.8

0.0152

KW-0808

Transferase

5 of 407

0.81

0.51

0.0216

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00696

Amino acid kinase family

3 of 6

2.42

1.85

0.00035

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036393

Acetylglutamate kinase-like superfamily

3 of 6

2.42

1.71

0.00065

IPR001048

Aspartate/glutamate/uridylate kinase

3 of 6

2.42

1.71

0.00065

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