Gasu_33850 protein (Galdieria sulphuraria) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Gasu_33850

Uncharacterized protein. (358 aa)

Predicted Functional Partners:

Gasu_49550

0.924

Gasu_48470

0.917

Gasu_14800

0.877

Gasu_41890

0.816

Gasu_09000

0.729

Gasu_18180

0.578

Gasu_53820

0.577

Gasu_14020

0.557

Gasu_49680

0.529

Gasu_27540

0.494

Your Current Organism:

Galdieria sulphuraria

NCBI taxonomy Id: 130081
Other names: G. sulphuraria, SAG 17.91

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Gasu_09000	Gasu_14020	M2X5R8	M2Y624	AP-2 complex subunit alpha isoform 1.	Sorting nexin 1 / phosphoinositide binding protein isoform 1.	0.528
Gasu_09000	Gasu_14800	M2X5R8	M2Y5K0	AP-2 complex subunit alpha isoform 1.	AP-3 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	0.721
Gasu_09000	Gasu_18180	M2X5R8	M2Y4C5	AP-2 complex subunit alpha isoform 1.	AP complex subunit beta.	0.995
Gasu_09000	Gasu_27540	M2X5R8	M2W2Q0	AP-2 complex subunit alpha isoform 1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.811
Gasu_09000	Gasu_33850	M2X5R8	M2XZX3	AP-2 complex subunit alpha isoform 1.	Uncharacterized protein.	0.729
Gasu_09000	Gasu_48470	M2X5R8	M2XV64	AP-2 complex subunit alpha isoform 1.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.830
Gasu_09000	Gasu_49680	M2X5R8	M2WUB9	AP-2 complex subunit alpha isoform 1.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.923
Gasu_09000	Gasu_53820	M2X5R8	M2XAX3	AP-2 complex subunit alpha isoform 1.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.852
Gasu_14020	Gasu_09000	M2Y624	M2X5R8	Sorting nexin 1 / phosphoinositide binding protein isoform 1.	AP-2 complex subunit alpha isoform 1.	0.528
Gasu_14020	Gasu_18180	M2Y624	M2Y4C5	Sorting nexin 1 / phosphoinositide binding protein isoform 1.	AP complex subunit beta.	0.726
Gasu_14020	Gasu_27540	M2Y624	M2W2Q0	Sorting nexin 1 / phosphoinositide binding protein isoform 1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.667
Gasu_14020	Gasu_33850	M2Y624	M2XZX3	Sorting nexin 1 / phosphoinositide binding protein isoform 1.	Uncharacterized protein.	0.557
Gasu_14020	Gasu_41890	M2Y624	M2XY44	Sorting nexin 1 / phosphoinositide binding protein isoform 1.	AP-1 complex subunit gamma.	0.735
Gasu_14020	Gasu_48470	M2Y624	M2XV64	Sorting nexin 1 / phosphoinositide binding protein isoform 1.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.671
Gasu_14020	Gasu_49550	M2Y624	M2VW87	Sorting nexin 1 / phosphoinositide binding protein isoform 1.	AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family.	0.623
Gasu_14020	Gasu_49680	M2Y624	M2WUB9	Sorting nexin 1 / phosphoinositide binding protein isoform 1.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.700
Gasu_14020	Gasu_53820	M2Y624	M2XAX3	Sorting nexin 1 / phosphoinositide binding protein isoform 1.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.731
Gasu_14800	Gasu_09000	M2Y5K0	M2X5R8	AP-3 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	AP-2 complex subunit alpha isoform 1.	0.721
Gasu_14800	Gasu_18180	M2Y5K0	M2Y4C5	AP-3 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	AP complex subunit beta.	0.444
Gasu_14800	Gasu_27540	M2Y5K0	M2W2Q0	AP-3 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.470

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Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.714

expected number of edges:

25

PPI enrichment p-value:

0.0932

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008380

RNA splicing

10 of 335

1.79

4.36

4.73e-14

GO:0006397

mRNA processing

10 of 420

1.69

3.84

2.19e-13

GO:0000398

mRNA splicing, via spliceosome

7 of 217

1.83

3.34

3.40e-09

GO:0051028

mRNA transport

4 of 90

1.97

2.11

4.38e-05

GO:0010467

Gene expression

11 of 1665

1.14

1.61

5.16e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

11 of 1169

1.29

2.14

1.77e-11

GO:0003729

mRNA binding

4 of 282

1.47

1.06

0.0040

GO:0000339

RNA cap binding

2 of 16

2.41

1.01

0.0143

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005846

Nuclear cap binding complex

2 of 2

3.32

1.55

0.0016

GO:0016607

Nuclear speck

4 of 269

1.49

1.18

0.0019

GO:0002102

Podosome

2 of 18

2.36

1.16

0.0072

GO:0016604

Nuclear body

5 of 483

1.33

1.09

0.0016

GO:0005681

Spliceosomal complex

3 of 167

1.57

0.97

0.0089

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37941135

(2023) Alternative splicing induced by bacterial pore-forming toxins sharpens CIRBP-mediated cell response to Listeria infection.

2 of 15

2.44

0.89

0.0234

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2649

RNA Polymerase II Transcription Termination, and mRNA Splicing - Major Pathway

11 of 130

2.25

8.36

1.64e-21

CL:2657

RNA recognition motif domain

8 of 71

2.37

6.63

5.76e-15

CL:2737

mRNA 3-end processing

4 of 22

2.58

3.37

4.30e-07

CL:2739

Mixed, incl. SRSF7, RNA recognition motif, and SRSF1, RNA recognition motif 1

3 of 13

2.68

2.46

2.89e-05

CL:2665

Mixed, incl. ROK, N-terminal, and TAF15/EWS/TLS family

3 of 13

2.68

2.46

2.89e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret03040

Spliceosome

9 of 120

2.19

6.81

3.94e-17

pret03015

mRNA surveillance pathway

3 of 76

1.91

1.63

0.00050

pret05168

Herpes simplex virus 1 infection

4 of 268

1.49

1.37

0.00050

pret03013

RNA transport

3 of 136

1.66

1.31

0.0015

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72163

mRNA Splicing - Major Pathway

11 of 251

1.96

6.14

6.02e-19

MAP-72172

mRNA Splicing

11 of 272

1.92

5.93

7.14e-19

MAP-73856

RNA Polymerase II Transcription Termination

7 of 78

2.27

5.56

8.26e-13

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

11 of 362

1.8

5.04

1.04e-17

MAP-72187

mRNA 3-end processing

6 of 67

2.27

4.73

1.08e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016607

Nuclear speck

4 of 79

2.02

2.03

8.00e-05

GOCC:0005846

Nuclear cap binding complex

2 of 3

3.14

1.64

0.0011

GOCC:0002102

Podosome

2 of 25

2.22

0.89

0.0225

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0694

RNA-binding

8 of 325

1.71

3.4

9.87e-11

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000504

RNA recognition motif domain

8 of 233

1.85

3.77

1.54e-10

IPR035979

RNA-binding domain superfamily

8 of 257

1.81

3.65

1.66e-10

IPR012677

Nucleotide-binding alpha-beta plait domain superfamily

8 of 264

1.8

3.62

1.66e-10

IPR012987

ROK, N-terminal

2 of 2

3.32

1.48

0.0022

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00360

RNA recognition motif

8 of 227

1.86

4.08

1.38e-11

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