STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ligADNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (671 aa)    
Predicted Functional Partners:
SHE37900.1
DNA ligase-1.
     
 0.915
leuS
leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 
 0.816
SHF45158.1
DNA polymerase III, alpha subunit.
 
  
 0.815
SHE48380.1
ATP-dependent DNA helicase RecQ.
  
  
 0.747
SHF38234.1
DNA helicase-2 / ATP-dependent DNA helicase PcrA.
 
  
 0.715
SHE56318.1
Bifunctional non-homologous end joining protein LigD.
     
 0.702
SHE56339.1
Bifunctional non-homologous end joining protein LigD.
     
 0.702
ruvB
Holliday junction DNA helicase subunit RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
  
   
 0.682
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
   
 0.676
SHF38669.1
16S rRNA (cytosine967-C5)-methyltransferase.
  
    0.670
Your Current Organism:
Chryseobacterium takakiae
NCBI taxonomy Id: 1302685
Other names: CGMCC 1.12488, Chryseobacterium sp. AG1-2, Chryseobacterium takakiae Zhao et al. 2015, DSM 26898, strain AG1-2
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