STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KXU14196.1Guanine-hypoxanthine permease. (478 aa)    
Predicted Functional Partners:
PurL
Phosphoribosylformylglycinamidine synthase, synthetase subunit / glutamine amidotransferase subunit.
  
  
 0.866
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.616
KXU14195.1
Membrane-bound protease, CAAX family.
       0.616
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.609
KXU14197.1
Cof protein, HD superfamily hydrolase.
       0.564
purD
Phosphoribosylamine--glycine ligase; Belongs to the GARS family.
  
  
 0.546
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family.
  
  
 0.540
purE
Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
    0.537
purK
Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
  
    0.515
KXU13762.1
Uracil permease.
 
  
 0.503
Your Current Organism:
Streptococcus oralis
NCBI taxonomy Id: 1303
Other names: ATCC 35037, CCUG 13229, CCUG 24891, CIP 102922, DSM 20627, JCM 12997, LMG 14532, LMG:14532, NCTC 11427, S. oralis, strain LVG 1, strain PB 182, strain SK23
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