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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rpoEDNA-directed RNA polymerase, delta subunit; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family. (191 aa)    
Predicted Functional Partners:
KXU58973.1
Hypothetical protein; Psort location: Cytoplasmic, score: 8.96; Belongs to the UPF0356 family.
  
   0.886
rpoZ
DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
 
 0.871
spxA
Regulatory protein spx; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily.
   
 
 0.791
KXU56655.1
Hypothetical protein; KEGG: suh:SAMSHR1132_05230 0.00086 hypothetical protein; K00868 pyridoxine kinase.
  
     0.738
KXU59268.1
Hypothetical protein; KEGG: say:TPY_3350 6.6e-05 ruvX; Holliday junction resolvase; K07447 putative holliday junction resolvase; Belongs to the UPF0473 family.
  
     0.732
KXU59134.1
Bacterial ABC transporter protein EcsB; Psort location: CytoplasmicMembrane, score: 10.00.
  
     0.718
KXU56160.1
Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.
  
     0.711
EzrA
Septation ring formation regulator EzrA; KEGG: tva:TVAG_387410 4.5e-09 viral A-type inclusion protein; K02331 DNA polymerase phi subunit; Psort location: Cytoplasmic, score: 8.96.
  
    0.710
sigA
RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
   
 
 0.694
MecA
Negative regulator of genetic competence; Psort location: Cytoplasmic, score: 9.97.
  
     0.690
Your Current Organism:
Streptococcus salivarius
NCBI taxonomy Id: 1304
Other names: ATCC 7073, CCUG 11878, CCUG 17825, CCUG 50207, CIP 102503, DSM 20560, JCM 5707, LMG 11489, LMG:11489, NCIMB 701779, NCTC 8618, S. salivarius, Streptococcus salivarius subsp. salivarius, Streptococcus sp. FStet12, Streptococcus sp. HSISS4
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