STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)    
Predicted Functional Partners:
PurB1
Adenylosuccinate lyase; KEGG: stl:stu0045 3.6e-227 purB; adenylosuccinate lyase K01756; Psort location: Cytoplasmic, score: 9.97.
 
 0.992
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.988
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: stj:SALIVA_0047 3.0e-271 purH; bifunctional purine biosynthesis protein purH; Psort location: Cytoplasmic, score: 9.97.
  
 0.975
PurL
KEGG: stj:SALIVA_0041 0. purL; phosphoribosylformylglycinamidine synthase II (FGAM synthase) (FGAMS) (Formylglycinamide ribotide amidotransferase) (FGARAT) (Formylglycinamide ribotide synthetase); Psort location: Cytoplasmic, score: 9.97.
  
  
 0.961
Hpt
KEGG: ssr:SALIVB_0012 1.3e-89 hpt; hypoxanthine-guanine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.941
PyrB
KEGG: stf:Ssal_01641 2.1e-160 pyrB; aspartate carbamoyltransferase; K00609 aspartate carbamoyltransferase catalytic subunit; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.935
argG
KEGG: stw:Y1U_C1702 3.7e-209 argininosuccinate synthase; K01940 argininosuccinate synthase; Psort location: Cytoplasmic, score: 9.97; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
  
 
 0.934
AsnA
Aspartate--ammonia ligase; KEGG: stj:SALIVA_0358 5.5e-176 asnA; aspartate--ammonia ligase (Asparagine synthetase A); Psort location: Cytoplasmic, score: 10.00.
    
  0.901
AnsB
L-asparaginase, type II; KEGG: stj:SALIVA_1788 1.6e-162 ansB; putative L-asparaginase (L-ASNase) (L-asparagine amidohydrolase); Psort location: Cytoplasmic, score: 9.26.
     
  0.900
guaA
GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.
 
  
 0.847
Your Current Organism:
Streptococcus salivarius
NCBI taxonomy Id: 1304
Other names: ATCC 7073, CCUG 11878, CCUG 17825, CCUG 50207, CIP 102503, DSM 20560, JCM 5707, LMG 11489, LMG:11489, NCIMB 701779, NCTC 8618, S. salivarius, Streptococcus salivarius subsp. salivarius, Streptococcus sp. FStet12, Streptococcus sp. HSISS4
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