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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvDKEGG: stj:SALIVA_1668 8.9e-295 ilvD; dihydroxy-acid dehydratase; Psort location: Cytoplasmic, score: 9.97; Belongs to the IlvD/Edd family. (552 aa)    
Predicted Functional Partners:
BcaT
Branched-chain-amino-acid transaminase; KEGG: stf:Ssal_01567 2.2e-179 ilvE; branched-chain amino acid aminotransferase; K00826 branched-chain amino acid aminotransferase; Psort location: Cytoplasmic, score: 9.97.
  
 0.966
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.946
ilvB
Acetolactate synthase, large subunit; KEGG: stj:SALIVA_1941 3.0e-294 ilvB; acetolactate synthase; Psort location: Cytoplasmic, score: 9.97.
  
 0.915
KXU58282.1
KEGG: stf:Ssal_00131 0. ilvD; dihydroxy-acid dehydratase; K01687 dihydroxy-acid dehydratase; Psort location: Cytoplasmic, score: 9.97.
  
  
 
0.908
AspC2B
Putative aminotransferase AlaT; KEGG: ssr:SALIVB_1752 4.8e-216 yfbQ; Aminotransferase yfbQ K14260; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.908
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.867
KXU58617.1
Aminodeoxychorismate synthase, component I; KEGG: stj:SALIVA_1250 6.3e-262 pabB; para-aminobenzoate synthetase; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.782
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
  
 0.781
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
  
 0.778
IlvH
KEGG: ssr:SALIVB_2010 2.1e-73 ilvH; acetolactate synthase small subunit K01653; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.768
Your Current Organism:
Streptococcus salivarius
NCBI taxonomy Id: 1304
Other names: ATCC 7073, CCUG 11878, CCUG 17825, CCUG 50207, CIP 102503, DSM 20560, JCM 5707, LMG 11489, LMG:11489, NCIMB 701779, NCTC 8618, S. salivarius, Streptococcus salivarius subsp. salivarius, Streptococcus sp. FStet12, Streptococcus sp. HSISS4
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