STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DnaK2DnaK family protein; KEGG: ctx:Clo1313_0933 3.1e-63 chaperone protein DnaK K04043; Psort location: Cytoplasmic, score: 9.97. (532 aa)    
Predicted Functional Partners:
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
 0.988
grpE
Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]
 
 0.972
groL
Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.933
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
  
 
0.923
KXU58916.1
ABC transporter, ATP-binding protein; KEGG: lsp:Bsph_1357 9.7e-28 potA; spermidine/putrescine import ATP-binding protein; K11072 spermidine/putrescine transport system ATP-binding protein; Psort location: CytoplasmicMembrane, score: 7.88.
 
 
 0.916
KXU58500.1
Hypothetical protein; KEGG: stj:SALIVA_1154 6.7e-100 signal transduction histidine kinase LytS; Psort location: CytoplasmicMembrane, score: 10.00.
  
 0.864
fusA
Translation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...]
  
 0.854
ClpL
KEGG: ssr:SALIVB_1722 0. ATP-dependent Clp protease, ATP-binding subunit K04086; Psort location: Cytoplasmic, score: 9.97; Belongs to the ClpA/ClpB family.
  
 
 0.807
ClpC
ATPase family protein; KEGG: saa:SAUSA300_0510 1.3e-174 clpC; endopeptidase K03696; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.807
ClpE
Putative negative regulator of genetic competence ClpC/MecB; KEGG: snc:HMPREF0837_11672 0. clpE; ATP dependent protease K03697; Psort location: Cytoplasmic, score: 9.97; Belongs to the ClpA/ClpB family.
  
 
 0.807
Your Current Organism:
Streptococcus salivarius
NCBI taxonomy Id: 1304
Other names: ATCC 7073, CCUG 11878, CCUG 17825, CCUG 50207, CIP 102503, DSM 20560, JCM 5707, LMG 11489, LMG:11489, NCIMB 701779, NCTC 8618, S. salivarius, Streptococcus salivarius subsp. salivarius, Streptococcus sp. FStet12, Streptococcus sp. HSISS4
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