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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SipASignal peptidase I; KEGG: stj:SALIVA_1836 5.1e-109 sipA; signal peptidase I; Psort location: CytoplasmicMembrane, score: 10.00. (213 aa)    
Predicted Functional Partners:
SipB
Signal peptidase I; KEGG: stj:SALIVA_1008 1.5e-93 sipB; signal peptidase I; Psort location: CytoplasmicMembrane, score: 9.82.
  
  
 
0.919
lepA
GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.
  
 
 0.801
RnhB2
Ribonuclease HIII; KEGG: stj:SALIVA_1835 6.6e-148 rnhC; ribonuclease HIII (RNase HIII).
  
    0.765
RecD
Helicase, RecD/TraA family; KEGG: ssr:SALIVB_1902 0. recD; putative exodeoxyribonuclease V K03581; Psort location: Cytoplasmic, score: 9.97.
       0.641
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.535
MutS1
KEGG: btl:BALH_3397 3.7e-202 mutS; DNA mismatch repair protein MutS K03555; Psort location: Cytoplasmic, score: 9.97.
    
  0.530
MutL
KEGG: btk:BT9727_3509 5.6e-151 mutL; DNA mismatch repair protein K03572; Psort location: Cytoplasmic, score: 9.97.
  
 
  0.529
KXU58521.1
Type III restriction enzyme, res subunit; KEGG: hwc:Hqrw_2960 8.3e-05 rad25c; DNA repair helicase Rad25.
    
  0.523
RnhB1
Ribonuclease HII; KEGG: stj:SALIVA_1185 7.1e-128 ribonuclease HII (RNase HII); Psort location: Cytoplasmic, score: 9.97.
  
    0.521
KXU59623.1
KEGG: stf:Ssal_01980 1.4e-209 rseP; RIP metalloprotease RseP; K11749 regulator of sigma E protease; Psort location: CytoplasmicMembrane, score: 10.00.
 
  
 0.511
Your Current Organism:
Streptococcus salivarius
NCBI taxonomy Id: 1304
Other names: ATCC 7073, CCUG 11878, CCUG 17825, CCUG 50207, CIP 102503, DSM 20560, JCM 5707, LMG 11489, LMG:11489, NCIMB 701779, NCTC 8618, S. salivarius, Streptococcus salivarius subsp. salivarius, Streptococcus sp. FStet12, Streptococcus sp. HSISS4
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