STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sdaAAKEGG: stf:Ssal_00873 8.1e-143 sdaA; L-serine dehydratase, iron-sulfur-dependent subunit alpha; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 9.26. (289 aa)    
Predicted Functional Partners:
sdaAB
KEGG: stj:SALIVA_1305 6.2e-113 sdaAB; putative L-serine dehydratase, beta chain (SDH) (L-serine deaminase) (L-SD); Belongs to the iron-sulfur dependent L-serine dehydratase family.
 
 0.999
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.945
ilvA
Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.923
serB
KEGG: stj:SALIVA_1566 8.9e-105 serB; putative phosphoserine phosphatase; Psort location: Cytoplasmic, score: 9.97.
   
 
 0.913
cysE
KEGG: stf:Ssal_02089 5.9e-108 cysE; serine acetyltransferase; K00640 serine O-acetyltransferase; Psort location: Cytoplasmic, score: 9.97.
     
 0.906
TrpA
KEGG: stj:SALIVA_1645 4.2e-130 trpA; tryptophan synthase alpha chain; Psort location: Cytoplasmic, score: 9.97.
   
 
 0.903
trpB
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
  0.900
ThrB
Homoserine kinase; KEGG: stf:Ssal_01693 4.0e-141 thrB; homoserine kinase; K00872 homoserine kinase.
  
 
 0.827
Hom
KEGG: ssr:SALIVB_0491 7.6e-218 hom; homoserine dehydrogenase K00003; Psort location: Cytoplasmic, score: 9.97.
   
 
  0.822
MetA
KEGG: stj:SALIVA_0867 6.4e-166 metA; homoserine O-acetyltransferase (or homoserine O-succinyltransferase); Psort location: Cytoplasmic, score: 9.97.
     
 0.809
Your Current Organism:
Streptococcus salivarius
NCBI taxonomy Id: 1304
Other names: ATCC 7073, CCUG 11878, CCUG 17825, CCUG 50207, CIP 102503, DSM 20560, JCM 5707, LMG 11489, LMG:11489, NCIMB 701779, NCTC 8618, S. salivarius, Streptococcus salivarius subsp. salivarius, Streptococcus sp. FStet12, Streptococcus sp. HSISS4
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.