STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (185 aa)    
Predicted Functional Partners:
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: stj:SALIVA_0047 3.0e-271 purH; bifunctional purine biosynthesis protein purH; Psort location: Cytoplasmic, score: 9.97.
 
 0.999
purD
KEGG: stf:Ssal_02135 5.8e-220 purD; phosphoribosylamine--glycine ligase; K01945 phosphoribosylamine--glycine ligase; Psort location: Cytoplasmic, score: 9.97; Belongs to the GARS family.
 
 0.999
purM
KEGG: ssr:SALIVB_0046 7.0e-176 purM; phosphoribosylformylglycinamidine cyclo-ligase K01933; Psort location: Cytoplasmic, score: 9.97.
  
 0.998
PurL
KEGG: stj:SALIVA_0041 0. purL; phosphoribosylformylglycinamidine synthase II (FGAM synthase) (FGAMS) (Formylglycinamide ribotide amidotransferase) (FGARAT) (Formylglycinamide ribotide synthetase); Psort location: Cytoplasmic, score: 9.97.
  
 
 0.979
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
 
 0.972
purK
Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
 
  
 0.963
purE
Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
 
  
 0.956
PurB1
Adenylosuccinate lyase; KEGG: stl:stu0045 3.6e-227 purB; adenylosuccinate lyase K01756; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.871
KXU57602.1
Hypothetical protein; KEGG: ste:STER_0049 1.1e-26 phosphoribosylaminoimidazole-succinocarboxamide synthase K01923.
  
 
 0.802
purC
Phosphoribosylaminoimidazolesuccinocarboxamide synthase; KEGG: scp:HMPREF0833_11503 9.6e-92 purC; phosphoribosylaminoimidazole-succinocarboxamide synthetase K01923; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.802
Your Current Organism:
Streptococcus salivarius
NCBI taxonomy Id: 1304
Other names: ATCC 7073, CCUG 11878, CCUG 17825, CCUG 50207, CIP 102503, DSM 20560, JCM 5707, LMG 11489, LMG:11489, NCIMB 701779, NCTC 8618, S. salivarius, Streptococcus salivarius subsp. salivarius, Streptococcus sp. FStet12, Streptococcus sp. HSISS4
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