STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa)    
Predicted Functional Partners:
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: stj:SALIVA_0047 3.0e-271 purH; bifunctional purine biosynthesis protein purH; Psort location: Cytoplasmic, score: 9.97.
  
 0.988
fhs
KEGG: stf:Ssal_00941 1.3e-291 fhs; formate--tetrahydrofolate ligase; K01938 formate--tetrahydrofolate ligase; Psort location: Cytoplasmic, score: 8.96.
  
 0.968
AcoL2
Dihydrolipoyl dehydrogenase; KEGG: stj:SALIVA_1069 3.7e-257 adhD; putative dihydrolipoamide dehydrogenase; Psort location: Cytoplasmic, score: 9.97.
  
 0.966
PurL
KEGG: stj:SALIVA_0041 0. purL; phosphoribosylformylglycinamidine synthase II (FGAM synthase) (FGAMS) (Formylglycinamide ribotide amidotransferase) (FGARAT) (Formylglycinamide ribotide synthetase); Psort location: Cytoplasmic, score: 9.97.
  
  
 0.955
sdaAB
KEGG: stj:SALIVA_1305 6.2e-113 sdaAB; putative L-serine dehydratase, beta chain (SDH) (L-serine deaminase) (L-SD); Belongs to the iron-sulfur dependent L-serine dehydratase family.
  
 
 0.947
sdaAA
KEGG: stf:Ssal_00873 8.1e-143 sdaA; L-serine dehydratase, iron-sulfur-dependent subunit alpha; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 9.26.
  
 
 0.945
serB
KEGG: stj:SALIVA_1566 8.9e-105 serB; putative phosphoserine phosphatase; Psort location: Cytoplasmic, score: 9.97.
  
 0.940
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.939
AcoL1
KEGG: stj:SALIVA_0696 9.9e-225 lpdA; dihydrolipoyl dehydrogenase (dihydrolipoamide dehydrogenase) (E3 component of 2-oxoglutarate dehydrogenase complex); Psort location: Cytoplasmic, score: 9.97.
  
 0.938
ilvA
Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
    
 0.928
Your Current Organism:
Streptococcus salivarius
NCBI taxonomy Id: 1304
Other names: ATCC 7073, CCUG 11878, CCUG 17825, CCUG 50207, CIP 102503, DSM 20560, JCM 5707, LMG 11489, LMG:11489, NCIMB 701779, NCTC 8618, S. salivarius, Streptococcus salivarius subsp. salivarius, Streptococcus sp. FStet12, Streptococcus sp. HSISS4
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