STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dltAD-alanine--poly(phosphoribitol) ligase, subunit 1; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to [...] (516 aa)    
Predicted Functional Partners:
dltC
D-alanine--poly(phosphoribitol) ligase, subunit 2; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
 
 0.999
dltB
Putative protein DltB; Could be involved in the transport of activated D-alanine through the membrane.
 
  
 0.994
KXU58615.1
DltD protein.
 
  
 0.993
FabD
[acyl-carrier-protein] S-malonyltransferase; KEGG: stj:SALIVA_0366 1.1e-147 fabD; malonyl CoA-acyl carrier protein transacylase; Psort location: Cytoplasmic, score: 9.97.
 
  
 0.918
Ddl
KEGG: ssr:SALIVB_1682 7.2e-174 ddl; D-alanine--D-alanine ligase K01921; Psort location: Cytoplasmic, score: 9.97.
   
 
 0.915
KXU56482.1
Putative serine 3-dehydrogenase; KEGG: stc:str0704 2.2e-124 short chain dehydrogenase/reductase family oxidoreductase; K00540; Psort location: Cytoplasmic, score: 9.97.
 
  
 0.902
acpP
Putative acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
  
 0.844
KXU57603.1
Putative acyl carrier protein; KEGG: cgr:CAGL0J04664g 1.9e-08 hypothetical protein; K03955 NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1; Psort location: Cytoplasmic, score: 8.96.
  
 0.844
KXU58611.1
Hypothetical protein; Psort location: CytoplasmicMembrane, score: 9.82.
       0.768
KXU57356.1
Hypothetical protein; KEGG: lsl:LSL_1018 0.0031 cellulose synthase catalytic subunit K00694.
 
     0.746
Your Current Organism:
Streptococcus salivarius
NCBI taxonomy Id: 1304
Other names: ATCC 7073, CCUG 11878, CCUG 17825, CCUG 50207, CIP 102503, DSM 20560, JCM 5707, LMG 11489, LMG:11489, NCIMB 701779, NCTC 8618, S. salivarius, Streptococcus salivarius subsp. salivarius, Streptococcus sp. FStet12, Streptococcus sp. HSISS4
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.