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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fhsKEGG: stf:Ssal_00941 1.3e-291 fhs; formate--tetrahydrofolate ligase; K01938 formate--tetrahydrofolate ligase; Psort location: Cytoplasmic, score: 8.96. (556 aa)    
Predicted Functional Partners:
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: stj:SALIVA_0047 3.0e-271 purH; bifunctional purine biosynthesis protein purH; Psort location: Cytoplasmic, score: 9.97.
  
 0.982
KXU58007.1
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; KEGG: ste:STER_0660 1.2e-139 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase; K01491 methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.972
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.968
PurL
KEGG: stj:SALIVA_0041 0. purL; phosphoribosylformylglycinamidine synthase II (FGAM synthase) (FGAMS) (Formylglycinamide ribotide amidotransferase) (FGARAT) (Formylglycinamide ribotide synthetase); Psort location: Cytoplasmic, score: 9.97.
  
 
 0.960
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
  
 0.729
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
 
 0.674
guaA
GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.
  
  
 0.666
KXU57602.1
Hypothetical protein; KEGG: ste:STER_0049 1.1e-26 phosphoribosylaminoimidazole-succinocarboxamide synthase K01923.
  
 
 0.662
purC
Phosphoribosylaminoimidazolesuccinocarboxamide synthase; KEGG: scp:HMPREF0833_11503 9.6e-92 purC; phosphoribosylaminoimidazole-succinocarboxamide synthetase K01923; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.662
purD
KEGG: stf:Ssal_02135 5.8e-220 purD; phosphoribosylamine--glycine ligase; K01945 phosphoribosylamine--glycine ligase; Psort location: Cytoplasmic, score: 9.97; Belongs to the GARS family.
  
 
 0.631
Your Current Organism:
Streptococcus salivarius
NCBI taxonomy Id: 1304
Other names: ATCC 7073, CCUG 11878, CCUG 17825, CCUG 50207, CIP 102503, DSM 20560, JCM 5707, LMG 11489, LMG:11489, NCIMB 701779, NCTC 8618, S. salivarius, Streptococcus salivarius subsp. salivarius, Streptococcus sp. FStet12, Streptococcus sp. HSISS4
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