STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DprAKEGG: apb:SAR116_0616 5.4e-43 DNA protecting protein DprA K04096; Psort location: Cytoplasmic, score: 8.96. (279 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 0.888
ComGA
Type II/IV secretion system protein; KEGG: pfe:PSF113_0439 4.0e-31 xcpR; protein XcpR K02454; Psort location: Cytoplasmic, score: 9.97.
 
  
 0.842
SsbB
Single-strand binding family protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
 
  
 0.802
KXU59474.1
comF family protein; KEGG: bya:BANAU_3449 6.3e-17 comFC; competence protein ComFC K02242; Psort location: Cytoplasmic, score: 8.96.
 
 
 0.790
KXU56793.1
DNA internalization competence protein ComEC/Rec2-like protein; Psort location: CytoplasmicMembrane, score: 10.00.
 
  
 0.786
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity); Belongs to the RecA family.
 
 
 0.768
RadC
KEGG: apb:SAR116_0666 1.2e-22 DNA repair protein RadC K03630; Psort location: Cytoplasmic, score: 9.97.
   
  
 0.742
KXU56463.1
Peptidase, A24 family; KEGG: stf:Ssal_01387 4.1e-61 comC; prepilin peptidase type IV; K02236 leader peptidase (prepilin peptidase) / N-methyltransferase; Psort location: CytoplasmicMembrane, score: 10.00.
  
  
 0.706
RecJ
KEGG: stf:Ssal_01299 0. recJ; single-stranded-DNA-specific exonuclease RecJ; K07462 single-stranded-DNA-specific exonuclease; Psort location: Cytoplasmic, score: 9.97.
 
   
 0.655
RbgA
Ribosome biogenesis GTP-binding protein YlqF; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
  
    0.632
Your Current Organism:
Streptococcus salivarius
NCBI taxonomy Id: 1304
Other names: ATCC 7073, CCUG 11878, CCUG 17825, CCUG 50207, CIP 102503, DSM 20560, JCM 5707, LMG 11489, LMG:11489, NCIMB 701779, NCTC 8618, S. salivarius, Streptococcus salivarius subsp. salivarius, Streptococcus sp. FStet12, Streptococcus sp. HSISS4
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