STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AlsAcetolactate synthase; KEGG: stj:SALIVA_1169 7.5e-282 alsS; acetolactate synthase (Acetohydroxy-acid synthase) (ALS); Psort location: Cytoplasmic, score: 9.97. (558 aa)    
Predicted Functional Partners:
IlvH
KEGG: ssr:SALIVB_2010 2.1e-73 ilvH; acetolactate synthase small subunit K01653; Psort location: Cytoplasmic, score: 9.97.
 
 0.995
budA
KEGG: stf:Ssal_01038 7.2e-119 alsD; alpha-acetolactate decarboxylase; K01575 acetolactate decarboxylase; Psort location: Cytoplasmic, score: 8.96.
 
 
 0.982
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
  
 0.936
ilvA
Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 0.931
ilvB
Acetolactate synthase, large subunit; KEGG: stj:SALIVA_1941 3.0e-294 ilvB; acetolactate synthase; Psort location: Cytoplasmic, score: 9.97.
  
  
 
0.922
pflB
KEGG: ssr:SALIVB_1775 0. pfl; formate acetyltransferase K00656; Psort location: Cytoplasmic, score: 9.94.
     
 0.907
spxB
Pyruvate oxidase; KEGG: sgo:SGO_0292 0. spxB; pyruvate oxidase K00158; Psort location: CytoplasmicMembrane, score: 7.88; Belongs to the TPP enzyme family.
  
  
 
0.851
pyk
Pyruvate kinase; KEGG: stj:SALIVA_0892 2.2e-250 pyk; pyruvate kinase; Psort location: Cytoplasmic, score: 9.97.
  
 0.837
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
 0.834
AcoA2
KEGG: stj:SALIVA_1066 7.9e-168 acetoin dehydrogenase complex, E1 component,alpha subunit; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.819
Your Current Organism:
Streptococcus salivarius
NCBI taxonomy Id: 1304
Other names: ATCC 7073, CCUG 11878, CCUG 17825, CCUG 50207, CIP 102503, DSM 20560, JCM 5707, LMG 11489, LMG:11489, NCIMB 701779, NCTC 8618, S. salivarius, Streptococcus salivarius subsp. salivarius, Streptococcus sp. FStet12, Streptococcus sp. HSISS4
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