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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KXU58510.1Ferrochelatase; KEGG: stj:SALIVA_1141 8.1e-198 hemH; ferrochelatase (Protoheme ferro-lyase) (Heme synthetase); Psort location: Cytoplasmic, score: 9.97. (370 aa)    
Predicted Functional Partners:
TatA
Twin arginine-targeting protein translocase, TatA/E family; Psort location: CytoplasmicMembrane, score: 9.82.
 
    0.567
KXU58509.1
Cation diffusion facilitator family transporter; KEGG: eci:UTI89_C0749 1.9e-24 zinc transporter ZitB K03295; Psort location: CytoplasmicMembrane, score: 10.00.
       0.558
AdhB1
GroES-like protein; KEGG: stj:SALIVA_1140 2.1e-176 adhB; alcohol dehydrogenase; Psort location: Cytoplasmic, score: 9.97.
     
 0.554
KXU56051.1
Hypothetical protein; KEGG: isc:IscW_ISCW000348 1.5e-15 secreted mucin MUC17, putative; Psort location: Extracellular, score: 9.64.
  
     0.533
KXU56052.1
Hypothetical protein; KEGG: isc:IscW_ISCW000348 1.9e-49 secreted mucin MUC17, putative.
  
     0.526
KXU56094.1
Putative cross-wall-targeting lipoprotein signal; KEGG: sce:YIR019C 1.4e-14 MUC1, FLO11, STA4; Muc1p; K01178 glucoamylase.
  
     0.511
TatC
KEGG: bqy:MUS_0612 2.6e-43 tatCY; sec-independent protein translocase protein K03118; Psort location: CytoplasmicMembrane, score: 10.00.
 
     0.507
HemN
Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
 
  
 0.474
metG
methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
   
  
 0.439
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.433
Your Current Organism:
Streptococcus salivarius
NCBI taxonomy Id: 1304
Other names: ATCC 7073, CCUG 11878, CCUG 17825, CCUG 50207, CIP 102503, DSM 20560, JCM 5707, LMG 11489, LMG:11489, NCIMB 701779, NCTC 8618, S. salivarius, Streptococcus salivarius subsp. salivarius, Streptococcus sp. FStet12, Streptococcus sp. HSISS4
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