Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
KXU58530.1Hypothetical protein; KEGG: apj:APJL_0654 0.00044 type III restriction-modification system restriction subunit; K01156 type III restriction enzyme. (763 aa)    
Predicted Functional Partners:
KXU58529.1
Hypothetical protein; Psort location: OuterMembrane, score: 8.97.
       0.693
KXU58593.1
Sortase family protein; KEGG: ssr:SALIVB_0826 1.5e-118 Sortase; K07284 sortase A.
 
     0.601
KXU59313.1
Hypothetical protein; KEGG: ctp:CTRG_05827 1.5e-08 hypothetical protein; K01183 chitinase.
      
 0.530
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
       0.512
KXU58594.1
Glyoxalase family protein; KEGG: sgg:SGGBAA2069_c11140 3.8e-49 glyoxylase I family protein K08234; Psort location: Cytoplasmic, score: 8.96.
       0.512
KXU58607.1
Hypothetical protein; KEGG: stz:SPYALAB49_000865 2.0e-130 phosphoenolpyruvate carboxylase; Psort location: Cytoplasmic, score: 8.96.
       0.490
KXU58963.1
CvpA family protein; Psort location: CytoplasmicMembrane, score: 10.00.
  
     0.462
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
       0.460
KXU58526.1
Hypothetical protein.
       0.449
KXU58527.1
Hypothetical protein.
       0.449
Your Current Organism:
Streptococcus salivarius
NCBI taxonomy Id: 1304
Other names: ATCC 7073, CCUG 11878, CCUG 17825, CCUG 50207, CIP 102503, DSM 20560, JCM 5707, LMG 11489, LMG:11489, NCIMB 701779, NCTC 8618, S. salivarius, Streptococcus salivarius subsp. salivarius, Streptococcus sp. FStet12, Streptococcus sp. HSISS4
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