STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrDDihydroorotate dehydrogenase 1B; Catalyzes the conversion of dihydroorotate to orotate. (318 aa)    
Predicted Functional Partners:
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
 0.986
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
 0.985
PyrF
KEGG: stj:SALIVA_1119 7.4e-117 pyrF; orotidine 5-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) (OMPdecase); Psort location: Cytoplasmic, score: 9.97.
 
  
 0.953
pyrD-2
Dihydroorotate dehydrogenase 1A; Catalyzes the conversion of dihydroorotate to orotate.
  
  
 
0.914
PyrB
KEGG: stf:Ssal_01641 2.1e-160 pyrB; aspartate carbamoyltransferase; K00609 aspartate carbamoyltransferase catalytic subunit; Psort location: Cytoplasmic, score: 9.97.
 
  
 0.836
carB
KEGG: stj:SALIVA_0508 0. carB; carbamoyl-phosphate synthase large chain; Psort location: Cytoplasmic, score: 9.97; Belongs to the CarB family.
 
 
 0.798
carA
KEGG: stj:SALIVA_0507 2.1e-192 carA; carbamoyl-phosphate synthase small chain; Psort location: Cytoplasmic, score: 9.97; Belongs to the CarA family.
 
  
 0.763
PheT
KEGG: stf:Ssal_00892 0. pheT; phenylalanyl-tRNA synthetase subunit beta; K01890 phenylalanyl-tRNA synthetase beta chain; Psort location: Cytoplasmic, score: 9.97.
  
  
 0.718
KXU57913.1
Uracil permease; KEGG: hiq:CGSHiGG_01870 6.5e-70 upp; uracil phosphoribosyltransferase K02824; Psort location: CytoplasmicMembrane, score: 10.00.
  
  
 0.703
PyrR
KEGG: stj:SALIVA_0504 2.0e-84 pyrR; bifunctional pyrimidine operon regulatory protein/uracil phosphoribosyltransferase; Psort location: Cytoplasmic, score: 9.97.
  
  
 0.643
Your Current Organism:
Streptococcus salivarius
NCBI taxonomy Id: 1304
Other names: ATCC 7073, CCUG 11878, CCUG 17825, CCUG 50207, CIP 102503, DSM 20560, JCM 5707, LMG 11489, LMG:11489, NCIMB 701779, NCTC 8618, S. salivarius, Streptococcus salivarius subsp. salivarius, Streptococcus sp. FStet12, Streptococcus sp. HSISS4
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