STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DutdUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (155 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 0.969
ComEB
Putative ComE operon protein 2; KEGG: ssr:SALIVB_1865 1.4e-76 putative dCMP deaminase K01493.
  
 0.946
KXU58583.1
ATP cone domain protein; KEGG: ssr:SALIVB_0816 9.5e-53 rnhB; Anaerobic ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score: 8.96.
    
 0.912
NrdD
KEGG: ssr:SALIVB_2084 0. nrdD; anaerobic ribonucleoside-triphosphate reductase K00527; Psort location: Cytoplasmic, score: 9.97.
    
 0.912
KXU58331.1
Hypothetical protein; KEGG: gpo:GPOL_c18530 8.4e-05 putative pyrazinamidase/nicotinamidase; K08281 nicotinamidase/pyrazinamidase.
     
 0.786
DnaN
KEGG: ssr:SALIVB_0002 1.2e-185 dnaN; beta subunit of DNA polymerase III; K02338 DNA polymerase III subunit beta; Psort location: Cytoplasmic, score: 9.26.
  
  
 0.777
NrdE
Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
  
 0.730
radA
DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
  
  
 0.699
tdk
Thymidine kinase; KEGG: stj:SALIVA_1264 4.6e-92 tdk; thymidine kinase; Psort location: Cytoplasmic, score: 9.97.
   
  
 0.672
KXU58486.1
KEGG: stj:SALIVA_1176 2.9e-60 ndk; nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase); Psort location: Cytoplasmic, score: 9.97.
   
 
 0.664
Your Current Organism:
Streptococcus salivarius
NCBI taxonomy Id: 1304
Other names: ATCC 7073, CCUG 11878, CCUG 17825, CCUG 50207, CIP 102503, DSM 20560, JCM 5707, LMG 11489, LMG:11489, NCIMB 701779, NCTC 8618, S. salivarius, Streptococcus salivarius subsp. salivarius, Streptococcus sp. FStet12, Streptococcus sp. HSISS4
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