STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KXU58007.1Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; KEGG: ste:STER_0660 1.2e-139 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase; K01491 methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. (284 aa)    
Predicted Functional Partners:
fhs
KEGG: stf:Ssal_00941 1.3e-291 fhs; formate--tetrahydrofolate ligase; K01938 formate--tetrahydrofolate ligase; Psort location: Cytoplasmic, score: 8.96.
 
 
 0.972
NusB
Transcription antitermination factor NusB; KEGG: tte:TTE1503 6.9e-08 Sun; tRNA and rRNA cytosine-C5-methylase; K03500 16S rRNA (cytosine967-C5)-methyltransferase; Psort location: Cytoplasmic, score: 8.96.
 
  
 0.809
PurL
KEGG: stj:SALIVA_0041 0. purL; phosphoribosylformylglycinamidine synthase II (FGAM synthase) (FGAMS) (Formylglycinamide ribotide amidotransferase) (FGARAT) (Formylglycinamide ribotide synthetase); Psort location: Cytoplasmic, score: 9.97.
  
  
 0.808
KXU58006.1
YjeF domain protein; KEGG: stj:SALIVA_0625 1.4e-120 ligA; NAD-dependent DNA ligase LigA.
       0.800
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.791
PurB1
Adenylosuccinate lyase; KEGG: stl:stu0045 3.6e-227 purB; adenylosuccinate lyase K01756; Psort location: Cytoplasmic, score: 9.97.
  
  
 0.771
SunL
Ribosomal RNA small subunit methyltransferase B; KEGG: stj:SALIVA_1502 9.1e-222 sunL; rNA-binding protein; Psort location: Cytoplasmic, score: 9.97.
  
  
 0.744
Fmt
KEGG: stj:SALIVA_1503 1.0e-158 fmt; methionyl-tRNA formyltransferase; Psort location: Cytoplasmic, score: 9.26.
 
  
 0.742
KXU58322.1
KEGG: stf:Ssal_00173 1.1e-81 5-formyltetrahydrofolate cyclo-ligase; K01934 5-formyltetrahydrofolate cyclo-ligase; Psort location: Cytoplasmic, score: 8.96.
    
 0.688
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: stj:SALIVA_0047 3.0e-271 purH; bifunctional purine biosynthesis protein purH; Psort location: Cytoplasmic, score: 9.97.
  
  
 0.679
Your Current Organism:
Streptococcus salivarius
NCBI taxonomy Id: 1304
Other names: ATCC 7073, CCUG 11878, CCUG 17825, CCUG 50207, CIP 102503, DSM 20560, JCM 5707, LMG 11489, LMG:11489, NCIMB 701779, NCTC 8618, S. salivarius, Streptococcus salivarius subsp. salivarius, Streptococcus sp. FStet12, Streptococcus sp. HSISS4
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