STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ptsHPhosphocarrier protein HPr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. (87 aa)    
Predicted Functional Partners:
ManL2
PTS system fructose IIA component; KEGG: stj:SALIVA_0309 5.1e-173 manX; PTS system mannose-specific EIIAB component (EIIAB-Man); Psort location: Cytoplasmic, score: 9.97.
  
 0.999
ManL1
KEGG: stj:SALIVA_0305 8.5e-171 manL; mannose PTS system component IIAB; Psort location: Cytoplasmic, score: 9.97.
  
 0.999
ptsI
Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
 
 0.999
KXU59317.1
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; KEGG: stj:SALIVA_0383 0. fruA; PTS system fructose-specific EIIABC component (EIIABC-Fru); Psort location: CytoplasmicMembrane, score: 10.00.
  
 
 0.996
ScrA2
KEGG: stf:Ssal_00287 0. scrA; PTS system sucrose-specific transporter subunit IIBC; K02808 PTS system, sucrose-specific IIA component; K02809 PTS system, sucrose-specific IIB component K02810; Psort location: CytoplasmicMembrane, score: 10.00.
  
 0.989
hprK
HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as probably the pyrophosphate- dependent phosphorylation of 'Ser-46' in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl- phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon so [...]
 
 
 
 0.923
ManN2
KEGG: ssr:SALIVB_0330 2.0e-155 ptnD; mannose-specific PTS system component IID K02796; Psort location: CytoplasmicMembrane, score: 10.00.
    
 0.915
ManN1
KEGG: stj:SALIVA_0303 4.6e-156 manN; mannose PTS system component IID; Psort location: CytoplasmicMembrane, score: 10.00.
    
 0.915
ManM2
Putative mannose permease IIC component; KEGG: ssr:SALIVB_0331 7.9e-129 putative mannose-specific phosphotransferase system component IIC K02795; Psort location: CytoplasmicMembrane, score: 10.00.
    
 0.913
ManM1
Putative mannose permease IIC component; KEGG: ssr:SALIVB_0327 5.0e-134 manM; putative mannose-specific phosphotransferase system component IIC K02795; Psort location: CytoplasmicMembrane, score: 10.00.
    
 0.913
Your Current Organism:
Streptococcus salivarius
NCBI taxonomy Id: 1304
Other names: ATCC 7073, CCUG 11878, CCUG 17825, CCUG 50207, CIP 102503, DSM 20560, JCM 5707, LMG 11489, LMG:11489, NCIMB 701779, NCTC 8618, S. salivarius, Streptococcus salivarius subsp. salivarius, Streptococcus sp. FStet12, Streptococcus sp. HSISS4
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