EOD00261.1 protein (Caldisalinibacter kiritimatiensis)

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query proteins and first shell of interactors

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

EOD00261.1

Regulatory protein, MarR. (146 aa)

Predicted Functional Partners:

EOD01497.1

0.867

EOD01156.1

0.867

EOD00147.1

0.867

EOD00262.1

0.794

EOD01212.1

0.650

EOD01215.1

0.650

EOC99485.1

0.499

EOC99486.1

0.499

EOD01736.1

0.488

EOD00260.1

0.481

Your Current Organism:

Caldisalinibacter kiritimatiensis

NCBI taxonomy Id: 1304284
Other names: C. kiritimatiensis, Caldisalinibacter kiritimatiensis Ben Hania et al. 2015, Clostridiaceae bacterium L21-TH-D2, DSM 26826, JCM 18664, strain L21-TH-D2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EOC99485.1	EOC99486.1	L21TH_2490	L21TH_2491	Hypothetical protein.	L-proline glycine betaine binding ABC transporter protein ProX / Osmotic adaptation.	0.999
EOC99485.1	EOD00261.1	L21TH_2490	L21TH_1735	Hypothetical protein.	Regulatory protein, MarR.	0.499
EOC99486.1	EOC99485.1	L21TH_2491	L21TH_2490	L-proline glycine betaine binding ABC transporter protein ProX / Osmotic adaptation.	Hypothetical protein.	0.999
EOC99486.1	EOD00261.1	L21TH_2491	L21TH_1735	L-proline glycine betaine binding ABC transporter protein ProX / Osmotic adaptation.	Regulatory protein, MarR.	0.499
EOD00147.1	EOD00261.1	L21TH_1798	L21TH_1735	PTS system, sucrose-specific component IIB / IIC.	Regulatory protein, MarR.	0.867
EOD00147.1	EOD01156.1	L21TH_1798	L21TH_0761	PTS system, sucrose-specific component IIB / IIC.	PTS system, glucose-specific component IIC / IIB.	0.999
EOD00147.1	EOD01212.1	L21TH_1798	L21TH_0751	PTS system, sucrose-specific component IIB / IIC.	PTS system, maltose and glucose-specific component IIC /IIB.	0.997
EOD00147.1	EOD01215.1	L21TH_1798	L21TH_0754	PTS system, sucrose-specific component IIB / IIC.	PTS system, trehalose-specific component IIB / IIC.	0.993
EOD00147.1	EOD01497.1	L21TH_1798	L21TH_0418	PTS system, sucrose-specific component IIB / IIC.	PTS system, glucose-specific component IIC / IIB.	0.999
EOD00147.1	EOD01736.1	L21TH_1798	L21TH_0186	PTS system, sucrose-specific component IIB / IIC.	Sensory box protein.	0.482
EOD00260.1	EOD00261.1	L21TH_1734	L21TH_1735	Hypothetical protein.	Regulatory protein, MarR.	0.481
EOD00260.1	EOD00262.1	L21TH_1734	L21TH_1736	Hypothetical protein.	Lipid A export ATP-binding/permease protein MsbA.	0.469
EOD00261.1	EOC99485.1	L21TH_1735	L21TH_2490	Regulatory protein, MarR.	Hypothetical protein.	0.499
EOD00261.1	EOC99486.1	L21TH_1735	L21TH_2491	Regulatory protein, MarR.	L-proline glycine betaine binding ABC transporter protein ProX / Osmotic adaptation.	0.499
EOD00261.1	EOD00147.1	L21TH_1735	L21TH_1798	Regulatory protein, MarR.	PTS system, sucrose-specific component IIB / IIC.	0.867
EOD00261.1	EOD00260.1	L21TH_1735	L21TH_1734	Regulatory protein, MarR.	Hypothetical protein.	0.481
EOD00261.1	EOD00262.1	L21TH_1735	L21TH_1736	Regulatory protein, MarR.	Lipid A export ATP-binding/permease protein MsbA.	0.794
EOD00261.1	EOD01156.1	L21TH_1735	L21TH_0761	Regulatory protein, MarR.	PTS system, glucose-specific component IIC / IIB.	0.867
EOD00261.1	EOD01212.1	L21TH_1735	L21TH_0751	Regulatory protein, MarR.	PTS system, maltose and glucose-specific component IIC /IIB.	0.650
EOD00261.1	EOD01215.1	L21TH_1735	L21TH_0754	Regulatory protein, MarR.	PTS system, trehalose-specific component IIB / IIC.	0.650

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.834

expected number of edges:

13

PPI enrichment p-value:

0.00204

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006265

DNA topological change

3 of 7

2.29

1.54

0.0013

GO:0006259

DNA metabolic process

5 of 233

0.99

0.54

0.0380

GO:0090304

Nucleic acid metabolic process

6 of 426

0.81

0.45

0.0422

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003918

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

3 of 4

2.54

1.97

0.00022

GO:0140657

ATP-dependent activity

5 of 157

1.16

0.89

0.0034

GO:0003690

Double-stranded DNA binding

2 of 13

1.85

0.89

0.0192

GO:0035639

Purine ribonucleoside triphosphate binding

7 of 580

0.74

0.53

0.0061

GO:0032555

Purine ribonucleotide binding

7 of 588

0.74

0.53

0.0061

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005694

Chromosome

3 of 26

1.72

1.16

0.0041

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0799

Topoisomerase

2 of 3

2.48

1.1

0.0096

KW-0413

Isomerase

3 of 59

1.37

0.76

0.0203

KW-0963

Cytoplasm

5 of 250

0.96

0.63

0.0127

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013760

DNA topoisomerase, type IIA-like domain superfamily

3 of 4

2.54

1.79

0.00049

IPR013759

DNA topoisomerase, type IIA, subunit B, C-terminal

2 of 2

2.66

0.9

0.0238

IPR013506

DNA topoisomerase, type IIA, subunit B, domain 2

2 of 2

2.66

0.9

0.0238

IPR001241

DNA topoisomerase, type IIA

2 of 2

2.66

0.9

0.0238

IPR006171

TOPRIM domain

2 of 5

2.26

0.8

0.0332

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00433

TopoisomeraseII

2 of 2

2.66

1.35

0.0035

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