Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (338 aa)    
Predicted Functional Partners:
AHC14805.1
Aspartate carbamoyltransferase/ Aspartate carbamoyltransferase regulatory chain (PyrI).
  
 
 0.995
AHC15055.1
Putative dihydropyrimidine dehydrogenase [NADP+], similar to dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.
  
 
 0.970
pyrD
Dihydroorotate dehydrogenase, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate.
  
 
 0.970
AHC16332.1
Putative dihydropyrimidine dehydrogenase [NADP+], similar to dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.
  
 
 0.970
AHC15623.1
Dihydroorotate dehydrogenase electron transfer subunit.
    
  0.905
carA
Carbamoyl-phosphate synthase small chain; Belongs to the CarA family.
   
  
 0.795
hisE
Phosphoribosyl-AMP cyclohydrolase/ Phosphoribosyl-ATP pyrophosphatase.
  
    0.794
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
  
    0.793
pyrE
Orotidine 5'-phosphate decarboxylase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP); Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
  
 
 0.720
AHC13570.1
Putative NagD-like phosphatase, Actinobacterial subfamily.
    
   0.658
Your Current Organism:
Salinispira pacifica
NCBI taxonomy Id: 1307761
Other names: DSM 27196, JCM 18663, S. pacifica, Salinispira pacifica Ben Hania et al. 2015, Spirochaeta sp. L21-RPul-D2, strain L21-RPul-D2
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.