AHC16288.1 protein (Salinispira pacifica) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

AHC16288.1

Lysyl-lysine 2,3-aminomutase. (346 aa)

Predicted Functional Partners:

AHC15722.1

0.900

lysA

0.808

AHC16256.1

0.706

AHC16642.1

0.705

AHC15910.1

0.682

AHC15279.1

0.665

AHC15885.1

0.665

AHC16279.1

0.597

AHC16289.1

0.593

AHC16287.1

0.546

Your Current Organism:

Salinispira pacifica

NCBI taxonomy Id: 1307761
Other names: DSM 27196, JCM 18663, S. pacifica, Salinispira pacifica Ben Hania et al. 2015, Spirochaeta sp. L21-RPul-D2, strain L21-RPul-D2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHC15279.1	AHC15885.1	L21SP2_1906	L21SP2_2533	Positive regulator of CheA protein activity (CheW).	Chemotaxis protein methyltransferase CheR.	0.898
AHC15279.1	AHC15910.1	L21SP2_1906	L21SP2_2558	Positive regulator of CheA protein activity (CheW).	Chemotaxis protein methyltransferase CheR.	0.999
AHC15279.1	AHC16279.1	L21SP2_1906	L21SP2_2933	Positive regulator of CheA protein activity (CheW).	Pyruvate-flavodoxin oxidoreductase.	0.799
AHC15279.1	AHC16288.1	L21SP2_1906	L21SP2_2942	Positive regulator of CheA protein activity (CheW).	Lysyl-lysine 2,3-aminomutase.	0.665
AHC15279.1	AHC16289.1	L21SP2_1906	L21SP2_2943	Positive regulator of CheA protein activity (CheW).	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	0.456
AHC15279.1	AHC16642.1	L21SP2_1906	L21SP2_3302	Positive regulator of CheA protein activity (CheW).	Chemotaxis protein methyltransferase CheR.	0.693
AHC15722.1	AHC16288.1	L21SP2_2369	L21SP2_2942	Carboxynorspermidine dehydrogenase, putative.	Lysyl-lysine 2,3-aminomutase.	0.900
AHC15722.1	lysA	L21SP2_2369	L21SP2_0015	Carboxynorspermidine dehydrogenase, putative.	Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.	0.927
AHC15885.1	AHC15279.1	L21SP2_2533	L21SP2_1906	Chemotaxis protein methyltransferase CheR.	Positive regulator of CheA protein activity (CheW).	0.898
AHC15885.1	AHC15910.1	L21SP2_2533	L21SP2_2558	Chemotaxis protein methyltransferase CheR.	Chemotaxis protein methyltransferase CheR.	0.978
AHC15885.1	AHC16279.1	L21SP2_2533	L21SP2_2933	Chemotaxis protein methyltransferase CheR.	Pyruvate-flavodoxin oxidoreductase.	0.779
AHC15885.1	AHC16288.1	L21SP2_2533	L21SP2_2942	Chemotaxis protein methyltransferase CheR.	Lysyl-lysine 2,3-aminomutase.	0.665
AHC15885.1	AHC16642.1	L21SP2_2533	L21SP2_3302	Chemotaxis protein methyltransferase CheR.	Chemotaxis protein methyltransferase CheR.	0.916
AHC15910.1	AHC15279.1	L21SP2_2558	L21SP2_1906	Chemotaxis protein methyltransferase CheR.	Positive regulator of CheA protein activity (CheW).	0.999
AHC15910.1	AHC15885.1	L21SP2_2558	L21SP2_2533	Chemotaxis protein methyltransferase CheR.	Chemotaxis protein methyltransferase CheR.	0.978
AHC15910.1	AHC16279.1	L21SP2_2558	L21SP2_2933	Chemotaxis protein methyltransferase CheR.	Pyruvate-flavodoxin oxidoreductase.	0.832
AHC15910.1	AHC16288.1	L21SP2_2558	L21SP2_2942	Chemotaxis protein methyltransferase CheR.	Lysyl-lysine 2,3-aminomutase.	0.682
AHC15910.1	AHC16289.1	L21SP2_2558	L21SP2_2943	Chemotaxis protein methyltransferase CheR.	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	0.902
AHC15910.1	AHC16642.1	L21SP2_2558	L21SP2_3302	Chemotaxis protein methyltransferase CheR.	Chemotaxis protein methyltransferase CheR.	0.978
AHC16256.1	AHC16288.1	L21SP2_2910	L21SP2_2942	Translation elongation factor P Lys34:lysine transferase; Belongs to the class-II aminoacyl-tRNA synthetase family.	Lysyl-lysine 2,3-aminomutase.	0.706

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

28

PPI enrichment p-value:

1.32e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

7 of 25

2.0

3.95

5.53e-10

GO:0006352

DNA-templated transcription, initiation

3 of 15

1.85

1.41

0.0014

GO:0019438

Aromatic compound biosynthetic process

8 of 270

1.02

1.06

1.90e-05

GO:0018130

Heterocycle biosynthetic process

8 of 294

0.98

0.99

3.13e-05

GO:1901362

Organic cyclic compound biosynthetic process

8 of 305

0.97

0.96

3.63e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

4 of 6

2.37

2.73

5.59e-06

GO:0016987

Sigma factor activity

3 of 15

1.85

1.33

0.0021

GO:0003677

DNA binding

7 of 307

0.91

0.75

0.0010

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

4 of 9

2.2

2.71

3.94e-06

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37075846

(2023) Transcription regulation by CarD in mycobacteria is guided by basal promoter kinetics.

4 of 6

2.37

2.55

1.31e-05

PMID:38741736

(2024) Function of the RNA-targeting class 2 type VI CRISPR Cas system of Rhodobacter capsulatus.

3 of 3

2.55

2.0

0.00020

PMID:30200857

(2018) Transcriptional Responses to ppGpp and DksA.

4 of 14

2.0

1.99

9.46e-05

PMID:34254822

(2021) Promoter Architecture Differences among Alphaproteobacteria and Other Bacterial Taxa.

3 of 5

2.33

1.84

0.00034

PMID:24516534

(2014) Transcriptional profiling of nitrogen fixation and the role of NifA in the diazotrophic endophyte Azoarcus sp. strain BH72.

4 of 23

1.79

1.67

0.00027

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:215

RNA polymerase, and Transcription termination

3 of 5

2.33

1.63

0.00087

CL:92

Ribosome, and RNA polymerase

4 of 67

1.32

0.8

0.0141

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

rsp03020

RNA polymerase

4 of 4

2.55

3.46

2.66e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

7 of 66

1.57

2.47

6.05e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

4 of 9

2.2

2.63

5.88e-06

KW-0731

Sigma factor

3 of 15

1.85

1.51

0.00081

KW-0804

Transcription

7 of 150

1.22

1.43

5.88e-06

KW-0548

Nucleotidyltransferase

4 of 45

1.5

1.36

0.00055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04545

Sigma-70, region 4

3 of 7

2.18

1.52

0.0013

PF04542

Sigma-70 region 2

3 of 11

1.98

1.39

0.0019

PF00140

Sigma-70 factor, region 1.2

2 of 2

2.55

1.12

0.0091

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000943

RNA polymerase sigma-70

3 of 4

2.42

1.62

0.00096

IPR007630

RNA polymerase sigma-70 region 4

3 of 7

2.18

1.47

0.0016

IPR014284

RNA polymerase sigma-70 like domain

3 of 11

1.98

1.28

0.0033

IPR013325

RNA polymerase sigma factor, region 2

3 of 11

1.98

1.28

0.0033

IPR007627

RNA polymerase sigma-70 region 2

3 of 11

1.98

1.28

0.0033

(more ...)

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