AHC16543.1 protein (Salinispira pacifica) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AHC16543.1

Hypothetical protein. (354 aa)

Predicted Functional Partners:

AHC16542.1

0.954

AHC16545.1

0.873

AHC13726.1

0.862

AHC16546.1

0.853

AHC16544.1

0.799

AHC16443.1

0.787

AHC16541.1

0.770

AHC16626.1

0.748

AHC16320.1

0.694

AHC14454.1

0.677

Your Current Organism:

Salinispira pacifica

NCBI taxonomy Id: 1307761
Other names: DSM 27196, JCM 18663, S. pacifica, Salinispira pacifica Ben Hania et al. 2015, Spirochaeta sp. L21-RPul-D2, strain L21-RPul-D2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHC13726.1	AHC16543.1	L21SP2_0286	L21SP2_3203	Hypothetical protein.	Hypothetical protein.	0.862
AHC14454.1	AHC16320.1	L21SP2_1038	L21SP2_2974	TPR domain protein.	RelA/SpoT domain protein.	0.491
AHC14454.1	AHC16543.1	L21SP2_1038	L21SP2_3203	TPR domain protein.	Hypothetical protein.	0.677
AHC16320.1	AHC14454.1	L21SP2_2974	L21SP2_1038	RelA/SpoT domain protein.	TPR domain protein.	0.491
AHC16320.1	AHC16543.1	L21SP2_2974	L21SP2_3203	RelA/SpoT domain protein.	Hypothetical protein.	0.694
AHC16443.1	AHC16543.1	L21SP2_3101	L21SP2_3203	Hypothetical protein.	Hypothetical protein.	0.787
AHC16541.1	AHC16542.1	L21SP2_3201	L21SP2_3202	Putative sucrose phosphorylase.	Peptidase T.	0.663
AHC16541.1	AHC16543.1	L21SP2_3201	L21SP2_3203	Putative sucrose phosphorylase.	Hypothetical protein.	0.770
AHC16541.1	AHC16544.1	L21SP2_3201	L21SP2_3204	Putative sucrose phosphorylase.	Hypothetical protein.	0.473
AHC16541.1	AHC16545.1	L21SP2_3201	L21SP2_3205	Putative sucrose phosphorylase.	Putative hydrolase.	0.656
AHC16541.1	AHC16546.1	L21SP2_3201	L21SP2_3206	Putative sucrose phosphorylase.	Glycosyl transferase group 1.	0.765
AHC16542.1	AHC16541.1	L21SP2_3202	L21SP2_3201	Peptidase T.	Putative sucrose phosphorylase.	0.663
AHC16542.1	AHC16543.1	L21SP2_3202	L21SP2_3203	Peptidase T.	Hypothetical protein.	0.954
AHC16542.1	AHC16544.1	L21SP2_3202	L21SP2_3204	Peptidase T.	Hypothetical protein.	0.781
AHC16542.1	AHC16545.1	L21SP2_3202	L21SP2_3205	Peptidase T.	Putative hydrolase.	0.880
AHC16542.1	AHC16546.1	L21SP2_3202	L21SP2_3206	Peptidase T.	Glycosyl transferase group 1.	0.839
AHC16543.1	AHC13726.1	L21SP2_3203	L21SP2_0286	Hypothetical protein.	Hypothetical protein.	0.862
AHC16543.1	AHC14454.1	L21SP2_3203	L21SP2_1038	Hypothetical protein.	TPR domain protein.	0.677
AHC16543.1	AHC16320.1	L21SP2_3203	L21SP2_2974	Hypothetical protein.	RelA/SpoT domain protein.	0.694
AHC16543.1	AHC16443.1	L21SP2_3203	L21SP2_3101	Hypothetical protein.	Hypothetical protein.	0.787

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.913

expected number of edges:

10

PPI enrichment p-value:

1.17e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

6 of 22

1.85

2.85

2.11e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

6 of 22

1.85

2.94

1.12e-07

GO:0002161

aminoacyl-tRNA editing activity

2 of 6

1.94

0.9

0.0193

GO:0005524

ATP binding

6 of 271

0.76

0.49

0.0171

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:332

Aminoacyl-tRNA biosynthesis

5 of 20

1.81

2.41

3.00e-06

CL:335

tRNA aminoacylation

4 of 12

1.94

2.24

1.83e-05

CL:478

Mixed, incl. Phosphoesterase MJ0912, and Threonyl/alanyl tRNA synthetase, SAD

3 of 6

2.12

1.88

0.00021

CL:129

Mixed, incl. Translation, and ATP-dependent activity

10 of 190

1.14

1.53

1.35e-08

CL:136

Translation, and Protein export

7 of 118

1.19

1.35

1.09e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

fsc00970

Aminoacyl-tRNA biosynthesis

7 of 24

1.88

3.79

2.56e-10

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

7 of 22

1.92

3.87

2.79e-10

KW-0648

Protein biosynthesis

7 of 43

1.63

2.81

5.80e-09

KW-0436

Ligase

8 of 58

1.56

2.79

6.95e-10

KW-0820

tRNA-binding

4 of 15

1.84

2.24

1.12e-05

KW-0963

Cytoplasm

8 of 169

1.09

1.29

1.11e-06

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01588

Putative tRNA binding domain

2 of 2

2.42

0.82

0.0321

PF00133

tRNA synthetases class I (I, L, M and V)

2 of 2

2.42

0.82

0.0321

PF08264

Anticodon-binding domain of tRNA ligase

2 of 3

2.24

0.81

0.0321

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045864

Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)

4 of 12

1.94

1.79

0.00022

IPR009080

Aminoacyl-tRNA synthetase, class Ia, anticodon-binding

3 of 7

2.05

1.34

0.0026

IPR018163

Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily

2 of 2

2.42

0.85

0.0284

IPR012947

Threonyl/alanyl tRNA synthetase, SAD

2 of 2

2.42

0.85

0.0284

IPR002547

tRNA-binding domain

2 of 2

2.42

0.85

0.0284

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00863

Threonyl and Alanyl tRNA synthetase second additional domain

2 of 2

2.42

1.18

0.0068

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