node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt | gmk_1 | L21SP4_01986 | L21SP4_00204 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.941 |
apt | gmk_2 | L21SP4_01986 | L21SP4_00523 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase. | 0.941 |
apt | gmk_3 | L21SP4_01986 | L21SP4_01362 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.941 |
apt | guaA | L21SP4_01986 | L21SP4_00885 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.991 |
apt | guaB_2 | L21SP4_01986 | L21SP4_01770 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.404 |
apt | hpt | L21SP4_01986 | L21SP4_00527 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.927 |
apt | punA | L21SP4_01986 | L21SP4_02436 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Purine nucleoside phosphorylase 1; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.933 |
apt | purA | L21SP4_01986 | L21SP4_02360 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.515 |
apt | purH | L21SP4_01986 | L21SP4_01826 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Bifunctional purine biosynthesis protein PurH. | 0.951 |
gmk_1 | apt | L21SP4_00204 | L21SP4_01986 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.941 |
gmk_1 | gmk_2 | L21SP4_00204 | L21SP4_00523 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Guanylate kinase. | 0.914 |
gmk_1 | gmk_3 | L21SP4_00204 | L21SP4_01362 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.901 |
gmk_1 | guaA | L21SP4_00204 | L21SP4_00885 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.951 |
gmk_1 | hpt | L21SP4_00204 | L21SP4_00527 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.919 |
gmk_2 | apt | L21SP4_00523 | L21SP4_01986 | Guanylate kinase. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.941 |
gmk_2 | gmk_1 | L21SP4_00523 | L21SP4_00204 | Guanylate kinase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.914 |
gmk_2 | gmk_3 | L21SP4_00523 | L21SP4_01362 | Guanylate kinase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.913 |
gmk_2 | guaA | L21SP4_00523 | L21SP4_00885 | Guanylate kinase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.941 |
gmk_2 | hpt | L21SP4_00523 | L21SP4_00527 | Guanylate kinase. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.908 |
gmk_3 | apt | L21SP4_01362 | L21SP4_01986 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.941 |