STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yitJ_2Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase. (308 aa)    
Predicted Functional Partners:
acsE_1
5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase.
  
 0.983
acsE_2
5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase.
  
 0.982
metH
Methionine synthase.
  
 0.979
metF
5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
 
 
 0.964
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.946
AKJ65656.1
5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.943
gcvT
Aminomethyltransferase.
  
 
 0.921
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 
 0.917
metK
S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.916
mdeA
Methionine gamma-lyase.
  
 
 0.914
Your Current Organism:
Kiritimatiella glycovorans
NCBI taxonomy Id: 1307763
Other names: DSM 26986, JCM 19195, K. glycovorans, Kiritimatiella glycovorans Spring et al. 2017, Verrucomicrobia bacterium L21-Fru-AB, bacterium L21-Fru-AB, strain L21-Fru-AB
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